Evidence map›Paper›PMID 28842499›Full record

ArticleThe Journal of biological chemistry2017

Human copper transporter ATP7B (Wilson disease protein) forms stable dimers

Samuel Jayakanthan, Lelita T Braiterman, Nesrin M Hasan, Vinzenz M Unger, Svetlana Lutsenko

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Epidemiology of Wilson's Disease and Pathogenic Variants of theInternational journal of molecular sciences · 2024
    Review
  5. Copper in Gynecological Diseases.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Wilson Disease: Update on Pathophysiology and Treatment.Frontiers in cell and developmental biology · 2022
    Review
  9. Article
  10. The CopA2-Type PFrontiers in microbiology · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Update on the Diagnosis and Management of Wilson Disease.Current gastroenterology reports · 2018
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Samuel JayakanthanFrom the Departments of Physiology and.
Lelita T BraitermanCell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and.
Nesrin M HasanFrom the Departments of Physiology and.
Vinzenz M Ungerthe Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208.
Svetlana LutsenkoFrom the Departments of Physiology and lutsenko@jhmi.edu.ORCID 0000-0001-5275-2587
Johns Hopkins University · USLukoil (Russia) · RUNorthwestern University · US

Funding

The role of transferrin receptor 2 in iron homeostasisP01GM067166 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI UNGER, VINZENZ · 2003 to 2013
$14.6M
Molecular Mechanisms of ATP-dependent Copper TransportersR01DK071865 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SVETLANA LUTSENKO · 2005 to 2026
$7.9M
Structure and Function of Mammalian Copper TransportersR01GM115211 · NIGMS · NORTHWESTERN UNIVERSITY · PI UNGER, VINZENZ · 2016 to 2017
$676k
NIDDK NIH HHS R01 DK071865NIGMS NIH HHS P01 GM067166NIGMS NIH HHS R01 GM115211
6 · The paper itself

Abstract

ATP7B is a copper-transporting P

Indexed as

Protein MultimerizationCopperCopper-Transporting ATPasesCrystallography, X-RayHEK293 CellsHepatolenticular DegenerationHumansModels, MolecularMutationProtein BindingProtein ConformationProtein DomainsProtein StabilityProtein TransportATP7B protein, humanCopperCopper-Transporting ATPasesATPasecalcium ATPasecopper transportdimerizationmembrane transport

Identifiers

PMID28842499
PMCPMC5704462
OpenAlexW2749286950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.