ArticleThe Journal of biological chemistry2017
The bacterial condensin MukB compacts DNA by sequestering supercoils and stabilizing topologically isolated loops.
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Analysis of Human miRNA Derived From Bladder Epithelial Cells Infected With Uropathogenic Escherichia coli.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Spatio-temporal organization of theEcoSal Plus · 2024Review
- MksB is a novel mycobacterial condensin that orchestrates spatiotemporal positioning of replication machinery.Scientific reports · 2024Article
- Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage.The EMBO journal · 2023Article
- Phylogenetic analysis and characterization of arsenic (As) transforming bacterial marker proteins following isolation of As-tolerant indigenous bacteria.Archives of microbiology · 2022Article
- Intersubunit and intrasubunit interactions driving the MukBEF ATPase.The Journal of biological chemistry · 2022Article
- The MukB-topoisomerase IV interaction mutually suppresses their catalytic activities.Nucleic acids research · 2022Article
- Bridging-induced phase separation induced by cohesin SMC protein complexes.Science advances · 2021Article
- The condensin holocomplex cycles dynamically between open and collapsed states.Nature structural & molecular biology · 2020Article
- A topological analysis of difference topology experiments of condensin with topoisomerase II.Biology open · 2020Article
- Article
- Architecture of the Escherichia coli nucleoid.PLoS genetics · 2019Article
- Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses.Journal of cell science · 2019Article
- Article
- Transient DNA Occupancy of the SMC Interarm Space in Prokaryotic Condensin.Molecular cell · 2019Article
- Dissecting DNA Compaction by the Bacterial Condensin MukB.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Small Molecule Condensin Inhibitors.ACS infectious diseases · 2018Article
- MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin.eLife · 2018Article
- The MukB-topoisomerase IV interaction is required for proper chromosome compaction.The Journal of biological chemistry · 2017Article
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6 authors.
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Abstract
MukB is a structural maintenance of chromosome-like protein required for DNA condensation. The complete condensin is a large tripartite complex of MukB, the kleisin, MukF, and an accessory protein, MukE. As found previously, MukB DNA condensation is a stepwise process. We have defined these steps topologically. They proceed first via the formation of negative supercoils that are sequestered by the protein followed by hinge-hinge interactions between MukB dimers that stabilize topologically isolated loops in the DNA. MukB itself is sufficient to mediate both of these topological alterations; neither ATP nor MukEF is required. We show that the MukB hinge region binds DNA and that this region of the protein is involved in sequestration of supercoils. Cells carrying mutations in the MukB hinge that reduce DNA condensation
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