ArticleJournal of immunology (Baltimore, Md. : 1950)2017
A20 Restrains Thymic Regulatory T Cell Development.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- The ubiquitin-editing enzyme A20 (TNFAIP3): mechanisms of activation, biological function, diseases and therapeutic targets.Molecular biomedicine · 2026Review
- NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells.Cell death and differentiation · 2025Article
- High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways.Science advances · 2025Article
- Dissecting the dual role of OTU family proteins in tumor progression and immune escape.Frontiers in immunology · 2025Review
- Mechanism study of ubiquitination in T cell development and autoimmune disease.Frontiers in immunology · 2024Review
- The Function of Ubiquitination in T-Cell Development.Advances in experimental medicine and biology · 2024Review
- Mistuned NF-κB signaling in lymphocytes: lessons from relevant inborn errors of immunity.Clinical and experimental immunology · 2023Article
- A20 as a Potential New Tool in Predicting Recurrence and Patient's Survival in Oral Squamous Cell Carcinoma.Cancers · 2023Article
- Protein ubiquitination in T cell development.Frontiers in immunology · 2022Review
- Targeting ubiquitin signaling for cancer immunotherapy.Signal transduction and targeted therapy · 2021Review
- Ubiquitin-Dependent Regulation of Treg Function and Plasticity.Advances in experimental medicine and biology · 2021Article
- RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity.Science advances · 2020Article
- Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression.Molecular biology reports · 2020Review
- A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity.Cold Spring Harbor perspectives in biology · 2020Review
- Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity.Frontiers in oncology · 2020Review
- Type I interferon signaling before hematopoietic stem cell transplantation lowers donor T cell activation via reduced allogenicity of recipient cells.Scientific reports · 2019Article
- A20: A multifunctional tool for regulating immunity and preventing disease.Cellular immunology · 2019Review
- Tumour necrosis factor signalling in health and disease.F1000Research · 2019Review
- Deubiquitinases as pivotal regulators of T cell functions.Frontiers of medicine · 2018Review
- Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer.Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 3 countries.
Julius Clemens FischerKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany.ORCID 0000-0002-6951-3416
Vera OttenKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany.
Maike KoberKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany.
Christoph DreesKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany.
Marc RosenbaumInstitut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany.
Martina SchmicklKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany.ORCID 0000-0002-0822-694X
Simon HeideggerKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany.ORCID 0000-0001-6394-5130
Rudi BeyaertDepartment of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium.ORCID 0000-0002-5704-582X
Geert van LooDepartment of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium.ORCID 0000-0002-8427-4775
Xian Chang LiImmunobiology & Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX 77030; and.ORCID 0000-0002-5981-2762
Christian PeschelKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany.ORCID 0000-0003-0547-2886
Marc Schmidt-SupprianKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany.
Tobias HaasKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany; tobias.haas@tum.de silvia.spoerl@tum.de hendrik.poeck@tum.de.ORCID 0000-0001-8986-5198
Silvia SpoerlKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany; tobias.haas@tum.de silvia.spoerl@tum.de hendrik.poeck@tum.de.ORCID 0000-0002-3065-1467
Hendrik PoeckKlinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany; tobias.haas@tum.de silvia.spoerl@tum.de hendrik.poeck@tum.de.
TUM Klinikum · DEGhent University Hospital · BEHouston Methodist · US
Funding
Control of Treg exhaustion by OX40R01AI106200 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI LI, XIAN CHANG · 2014 to 2025
$4.2MNIAID NIH HHS R01 AI106200
Abstract
Maintaining immune tolerance requires the production of Foxp3-expressing regulatory T (T
Indexed as
AnimalsApoptosisCD4-Positive T-LymphocytesCell DifferentiationFlow CytometryForkhead Transcription FactorsGene Expression RegulationGlucocorticoid-Induced TNFR-Related ProteinGraft vs Host DiseaseInterleukin-2Lymphocyte ActivationMiceNF-kappa BProto-Oncogene Proteins c-relSignal TransductionStem Cell TransplantationForkhead Transcription FactorsFoxp3 protein, mouseGlucocorticoid-Induced TNFR-Related ProteinInterleukin-2NF-kappa BProto-Oncogene Proteins c-relRela protein, mouseTnfaip3 protein, mouseTnfrsf18 protein, mouseTranscription Factor RelATumor Necrosis Factor alpha-Induced Protein 3
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.