ArticleNeurology2017
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In one paragraph
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Hippocampal 1H-MR spectroscopy metabolites are linked to CSF tau pathology in cognitively unimpaired older adults along the Alzheimer's continuum.Neurobiology of aging · 2026Article
- Associations between Aβ deposition and neurometabolic alterations in Alzheimer's disease: Insights from hybrid 3D MRSI-PET imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Understanding Proton Magnetic Resonance Spectroscopy Neurochemical Changes Using Alzheimer's Disease Biofluid, PET, Postmortem Pathology Biomarkers, and APOE Genotype.International journal of molecular sciences · 2024Review
- Article
- Linking alcohol use to Alzheimer's disease: Interactions with aging and APOE along immune pathways.Medical research archives · 2024Article
- Investigating the brain's neurochemical profile at midlife in relation to dementia risk factors.Brain communications · 2024Article
- APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PMBiomolecules · 2023Review
- Neurochemical Ameliorating of the Hippocampus in Dyslipidemic Alzheimer Patients Following Silymarin; a Double-Blind Placebo-Controlled Randomized Clinical Trial.Medical journal of the Islamic Republic of Iran · 2023Article
- Article
- Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.Neurobiology of aging · 2022Article
- Astrocytic function is associated with both amyloid-β and tau pathology in non-dementedBrain communications · 2022Article
- Article
- Frontal Metabolites and Alzheimer's Disease Biomarkers in Healthy Older Women and Women Diagnosed with Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2022Article
- The Brain Metabolic Signature in Superagers Using In VivoAJNR. American journal of neuroradiology · 2021Article
- Longitudinal Amyloid-β PET in Atypical Alzheimer's Disease and Frontotemporal Lobar Degeneration.Journal of Alzheimer's disease : JAD · 2020Article
- Association of Longitudinal β-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia.JAMA network open · 2019Article
- Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2019Article
- Frontal lobeNeurology · 2019Article
- Brain myoinositol as a potential marker of amyloid-related pathology: A longitudinal study.Neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 2 countries.
Zuzana NedelskaFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Scott A PrzybelskiFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Timothy G LesnickFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Christopher G SchwarzFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Val J LoweFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Mary M MachuldaFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Walter K KremersFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Michelle M MielkeFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Rosebud O RobertsFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Bradley F BoeveFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
David S KnopmanFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Ronald C PetersenFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Clifford R JackFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
Kejal KantarciFrom the Departments of Radiology (Z.N., C.G.S., V.J.L., C.R.J., K.K.), Health Sciences Research (S.A.P., T.G.L., W.K.K., M.M.M., R.O.R.), Psychiatry and Psychology (M.M.M.), and Neurology (M.M.M., R.O.R., B.F.B., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Department of Neurology (Z.N.), Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic. kantarci.kejal@mayo.edu.
Mayo Clinic · US
Funding
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6MTHE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PANKRATZ, V. SHANE · 1999 to 2018
$36.9MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MPREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1MRochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5MTraining - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4MSex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1MEpidemiology of Familial Late-Onset Alzheimer's DiseaseR01AG041797 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2012 to 2016
$4.2MEXTRAMURAL RES FACIL IMPROVEMENT PROG: POLYCYSTIC KIDNEY DISEASE, RENAL STUDIES,C06RR018898 · NCRR · MAYO CLINIC · PI BURNETT, JOHN C · 2004 to 2004
$2.3MPathological basis of MRS and DTI changes in neurodegenerative dementiaR01AG040042 · NIA · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2011 to 2015
$1.6MNCRR NIH HHS C06 RR018898NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG044170NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG040042NIA NIH HHS R01 AG041797NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG045390NINDS NIH HHS U54 NS092089
Abstract
objectiveTo assess whether noninvasive proton magnetic resonance spectroscopy (
methodsConsecutive participants aged 60 years and older (n = 594) from the Mayo Clinic Study of Aging who were CN at baseline and who underwent
resultsAmong all participants, a higher myo-inositol (mI)/creatine (
conclusionAmong CN older adults, early metabolic alterations on
Indexed as
Positron-Emission TomographyProton Magnetic Resonance SpectroscopyAgedAgingAmyloid beta-PeptidesApolipoprotein E4Aspartic AcidBrainCreatineFemaleFollow-Up StudiesHeterozygoteHumansInositolLongitudinal StudiesMaleAmyloid beta-PeptidesApolipoprotein E4Aspartic AcidCreatineInositolN-acetylaspartate
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.