Evidence map›Paper›PMID 28842422›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Sepsis reveals compartment-specific responses in intestinal proliferation and apoptosis in transgenic mice whose enterocytes re-enter the cell cycle.

John D Lyons, Nathan J Klingensmith, Shunsuke Otani, Rohit Mittal, Zhe Liang, Mandy L Ford, Craig M Coopersmith

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Cell death of intestinal epithelial cells in intestinal diseases.Sheng li xue bao : [Acta physiologica Sinica] · 2020
    Review
  4. A Novel Role for Necroptosis in the Pathogenesis of Necrotizing Enterocolitis.Cellular and molecular gastroenterology and hepatology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

John D LyonsDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Nathan J KlingensmithDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Shunsuke OtaniDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Rohit MittalDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Zhe LiangDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Mandy L FordDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Craig M CoopersmithDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA; cmcoop3@emory.edu.
Emory University · USChiba University · JP

Funding

Mechanisms of Intestinal Integrity in Sepsis and ShockR01GM072808 · NIGMS · WASHINGTON UNIVERSITY · PI COOPERSMITH, CRAIG M · 2005 to 2021
$5.1M
Critical Care Training ProgramT32GM095442 · NIGMS · EMORY UNIVERSITY · PI Craig M Coopersmith · 2011 to 2026
$4.7M
The Impact of Cancer on the Pathophysiology of SepsisR01GM104323 · NIGMS · EMORY UNIVERSITY · PI COOPERSMITH, CRAIG M, FORD, MANDY L · 2013 to 2021
$2.4M
The Impact of Chronic Alcohol Abuse on the Pathophysiology of SepsisR01GM109779 · NIGMS · EMORY UNIVERSITY · PI COOPERSMITH, CRAIG M, FORD, MANDY L · 2014 to 2017
$1.2M
Targeting 2B4 Coinhibitory Signals During Sepsis-Induced Immune DysregulationR01GM113228 · NIGMS · EMORY UNIVERSITY · PI COOPERSMITH, CRAIG M, FORD, MANDY L · 2015 to 2018
$1.2M
RIP-Mediated Signaling in Intestinal Epithelial Cell Death During SepsisF32GM117895 · NIGMS · EMORY UNIVERSITY · PI LYONS, JOHN DANIEL · 2016 to 2016
$28k
NIGMS NIH HHS F32 GM117895NIGMS NIH HHS R01 GM072808NIGMS NIH HHS R01 GM104323NIGMS NIH HHS R01 GM109779NIGMS NIH HHS R01 GM113228NIGMS NIH HHS T32 GM095442
6 · The paper itself

Abstract

Cell production and death are tightly regulated in the rapidly renewing gut epithelium, with proliferation confined to crypts and apoptosis occurring in villi and crypts. This study sought to determine how stress alters these compartmentalized processes. Wild-type mice made septic

Indexed as

AnimalsApoptosisBlotting, WesternCell CycleCell ProliferationEnterocytesFemaleIntestinal MucosaIntestinesMaleMiceMice, TransgenicSepsisbarriercritical illnesscyclingutstress

Identifiers

PMID28842422
PMCPMC5690387
OpenAlexW2747483647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.