ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Effect of Threat on Right dlPFC Activity during Behavioral Pattern Separation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Effects of novelty and reward-based fear extinction on memory generalization.Behaviour research and therapy · 2026Article
- Anxiety makes time pass quicker: neural correlates.Social cognitive and affective neuroscience · 2026Article
- Noninvasive ventromedial prefrontal cortex stimulation can enhance and impair affective learning from rewarding and threatening stimuli.Social cognitive and affective neuroscience · 2025Article
- Threat of shock increases distractor susceptibility during the short-term maintenance of visual information.Social cognitive and affective neuroscience · 2024Article
- Interleaved TMS/fMRI shows that threat decreases dlPFC-mediated top-down regulation of emotion processing.NPP - digital psychiatry and neuroscience · 2024Article
- A neural signature for the subjective experience of threat anticipation under uncertainty.Nature communications · 2024Article
- Leader-follower behavioural coordination and neural synchronization during intergroup conflict.Nature human behaviour · 2023Article
- Continuous Theta-Burst Stimulation to the Right Dorsolateral Prefrontal Cortex May Increase Potentiated Startle in Healthy Individuals.Biological psychiatry global open science · 2023Article
- The role of dlPFC laterality in the expression and regulation of anxiety.Neuropharmacology · 2023Review
- Differentiating distinct and converging neural correlates of types of systemic environmental exposures.Human brain mapping · 2022Article
- Differential Patterns of Delayed Emotion Circuit Maturation in Abused Girls With and Without Internalizing Psychopathology.The American journal of psychiatry · 2021Article
- Patients with anxiety disorders rely on bilateral dlPFC activation during verbal working memory.Social cognitive and affective neuroscience · 2020Article
- The 'Threat of Scream' paradigm: a tool for studying sustained physiological and subjective anxiety.Scientific reports · 2020Article
- Chronic stress, structural exposures and neurobiological mechanisms: A stimulation, discrepancy and deprivation model of psychosis.International review of neurobiology · 2020Review
- Oxygenation of the Prefrontal Cortex during Memory Interference.Journal of clinical medicine · 2019Article
- Implicit and explicit systems differently predict possible dangers.Scientific reports · 2019Article
- Neuroticism and Frontal EEG Asymmetry Correlated With Dynamic Facial Emotional Processing in Adolescents.Frontiers in psychology · 2019Article
- Viewing Another Act as You Would Creates Altruistic Desires Towards that Other.Frontiers in human neuroscience · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It has long been established that individuals with anxiety disorders tend to overgeneralize attributes of fearful stimuli to nonfearful stimuli, but there is little mechanistic understanding of the neural system that supports overgeneralization. To address this gap in our knowledge, this study examined effect of experimentally induced anxiety in humans on generalization using the behavioral pattern separation (BPS) paradigm. Healthy subjects of both sexes encoded and retrieved novel objects during periods of safety and threat of unpredictable shocks while we recorded brain activity with fMRI. During retrieval, subjects were instructed to differentiate among new, old, and altered images. We hypothesized that the hippocampus and dorsolateral prefrontal cortex (dlPFC) would play a key role in the effect of anxiety on BPS. The dlPFC, but not the hippocampus, showed increased activity for altered images compared with old images when retrieval occurred during periods of threat compared with safety. In addition, accuracy for altered items retrieved during threat was correlated with dlPFC activity. Together, these results suggest that overgeneralization in anxiety patients may be mediated by an inability to recruit the dlPFC, which mediates the cognitive control needed to overcome anxiety and differentiate between old and altered items during periods of threat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.