Evidence map›Paper›PMID 28842414›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism.

Daniel P Bermingham, J Andrew Hardaway, Osama Refai, Christian R Marks, Sam L Snider, Sarah M Sturgeon, William C Spencer, Roger J Colbran, David M Miller, Randy D Blakely

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Daniel P BerminghamDepartments of Pharmacology.
J Andrew HardawayDepartments of Pharmacology.ORCID 0000-0003-3893-2658
Osama RefaiDepartments of Pharmacology.ORCID 0000-0002-5870-5236
Christian R MarksMolecular Physiology and Biophysics.ORCID 0000-0002-9232-5261
Sam L SniderDepartments of Pharmacology.
Sarah M SturgeonDepartments of Pharmacology.ORCID 0000-0002-2076-3043
William C SpencerCell and Developmental Biology, and.ORCID 0000-0002-9700-8011
Roger J ColbranMolecular Physiology and Biophysics.ORCID 0000-0001-7401-8244
David M MillerCell and Developmental Biology, and.
Randy D BlakelyDepartments of Pharmacology, rblakely@health.fau.edu.ORCID 0000-0002-2182-6966
Institute of Pharmacology · CZInstitute of Molecular Biology and Biophysics · RUVanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Training in Fundamental NeuroscienceT32MH064913 · NIMH · VANDERBILT UNIVERSITY · PI IHRIE, REBECCA A, WINDER, DANNY G. · 2001 to 2022
$7.6M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
PRESYNAPTIC REGULATION OF C.ELEGANS DOPAMINE TRANSPORTERR01MH095044 · NIMH · VANDERBILT UNIVERSITY · PI BLAKELY, RANDY D. · 2012 to 2016
$2.2M
CaMKII, endocannabinoids, synaptic plasticity and motor functionR01NS078291 · NINDS · VANDERBILT UNIVERSITY · PI COLBRAN, ROGER J · 2012 to 2016
$1.8M
Identification and Characterization of a Novel Regulator of Dopamine SignalingF31DA035559 · NIDA · VANDERBILT UNIVERSITY · PI BERMINGHAM, DANIEL · 2013 to 2015
$82k
Presynaptic Mechanisms Regulating the Dopamine TransporterF31MH093102 · NIMH · VANDERBILT UNIVERSITY · PI HARDAWAY, JAMES ANDREW · 2010 to 2013
$75k
NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NICHD NIH HHS U54 HD083211NIDA NIH HHS F31 DA035559NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637NIMH NIH HHS F31 MH093102NIMH NIH HHS F31 MH109196NIMH NIH HHS R01 MH095044NIMH NIH HHS T32 MH064913NINDS NIH HHS R01 NS078291
6 · The paper itself

Abstract

The neurotransmitter dopamine (DA) regulates multiple behaviors across phylogeny, with disrupted DA signaling in humans associated with addiction, attention-deficit/ hyperactivity disorder, schizophrenia, and Parkinson's disease. The DA transporter (DAT) imposes spatial and temporal limits on DA action, and provides for presynaptic DA recycling to replenish neurotransmitter pools. Molecular mechanisms that regulate DAT expression, trafficking, and function, particularly

Indexed as

AnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCells, CulturedDopamineDopamine Plasma Membrane Transport ProteinsExtracellular Signal-Regulated MAP KinasesGene Expression Regulation, EnzymologicNeuronsrho-Associated KinasesCaenorhabditis elegans ProteinsDopamineDopamine Plasma Membrane Transport ProteinsExtracellular Signal-Regulated MAP KinasesMAPK15 protein, humanrho-Associated KinasesC. elegansdopaminegeneticskinaseneurotransmitterstransporters

Identifiers

PMID28842414
PMCPMC5607470
OpenAlexW2746395494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.