Evidence map›Paper›PMID 28842397›Full record

ArticleGenetics2017

Lipocalins Are Required for Apical Extracellular Matrix Organization and Remodeling in

Rachel Forman-Rubinsky, Jennifer D Cohen, Meera V Sundaram

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. A Lipocalin and a Hedgehog-related protein are partners in thebioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Pre-cuticle DPY-6 acts as a blueprint for aECM periodic organization inbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Apical spectrin organizes cortical actin filament bundles to patternbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. MLT-11 is necessary forbioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. bioRxiv : the preprint server for biology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rachel Forman-RubinskyDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104.
Jennifer D CohenDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104.
Meera V SundaramDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104 sundaram@mail.med.upenn.edu.ORCID 0000-0002-2940-8750
University of Pennsylvania · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIGMS NIH HHS T32 GM008216NIH HHS P40 OD010440
6 · The paper itself

Abstract

A lipid and glycoprotein-rich apical extracellular matrix (aECM) or glycocalyx lines exposed membranes in the body, and is particularly important to protect narrow tube integrity. Lipocalins ("fat cups") are small, secreted, cup-shaped proteins that bind and transport lipophilic cargo and are often found in luminal or aECM compartments such as mammalian plasma, urine, or tear film. Although some lipocalins can bind known aECM lipids and/or matrix metalloproteinases, it is not known if and how lipocalins affect aECM structure due to challenges in visualizing the aECM in most systems. Here we show that two

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEpithelial CellsExtracellular MatrixGlycocalyxLipocalinsMucinsCaenorhabditis elegans ProteinsLET-653 protein, C elegansLipocalinsMucinsapical extracellular matrixC. eleganscuticleexcretory systemlipocalin

Identifiers

PMID28842397
PMCPMC5629328
OpenAlexW2750370132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.