Evidence map›Paper›PMID 28842322›Full record

ArticleThe Journal of investigative dermatology2017

Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain.

Rhiannon M Kelsh-Lasher, Anthony Ambesi, Ceyda Bertram, Paula J McKeown-Longo

Open access · greenAbstract read
In one paragraph

Article in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Targeting Extra Domain A of Fibronectin to Improve Noninvasive Detection of Triple-Negative Breast Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Toll-like receptors and integrins crosstalk.Frontiers in immunology · 2024
    Review
  13. Review
  14. Poly(l-lactic acid) Scaffold Releasing an αACS applied bio materials · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Toll-Like Receptor 4 Signaling in the Trabecular Meshwork.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rhiannon M Kelsh-LasherDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.
Anthony AmbesiDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.
Ceyda BertramDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.
Paula J McKeown-LongoDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA. Electronic address: mckeowp@mail.amc.edu.
Albany Medical Center Hospital · US

Funding

VITRONECTIN--STRUCTURE/FUNCTIONR01CA058626 · NCI · ALBANY MEDICAL COLLEGE · PI MC KEOWN-LONGO, PAULA J · 1993 to 2012
$3.3M
Remodeling of the Fibronectin Matrix: Role in Chronic WoundsR21AR067956 · NIAMS · ALBANY MEDICAL COLLEGE · PI MC KEOWN-LONGO, PAULA J · 2016 to 2017
$382k
Regulation of Fibronectin Matrix Assembly by uPARR56CA058626 · NCI · ALBANY MEDICAL COLLEGE · PI MC KEOWN-LONGO, PAULA J · 2007 to 2007
$242k
NCI NIH HHS R01 CA058626NCI NIH HHS R56 CA058626NIAMS NIH HHS R21 AR067956
6 · The paper itself

Abstract

Alternative splicing of fibronectin increases expression of the EDA

Indexed as

Alternative SplicingExtracellular MatrixFibronectinsFibrosisGene Expression ProfilingGene Expression RegulationHumansInflammationIntegrin alpha4beta1Interleukin-10Interleukin-13OsteopontinProtein DomainsRNA, Small InterferingSignal TransductionToll-Like Receptor 4extra domain A fibronectin, humanFibronectinsFN1 protein, humanIL10 protein, humanIL13 protein, humanIntegrin alpha4beta1Interleukin-10Interleukin-13OsteopontinRNA, Small InterferingTLR4 protein, humanToll-Like Receptor 4Tumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1

Identifiers

PMID28842322
PMCPMC6736604
OpenAlexW2746591356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.