Evidence map›Paper›PMID 28842114›Full record

ArticleBiological psychiatry2018

Intergenerational Effect of Maternal Exposure to Childhood Maltreatment on Newborn Brain Anatomy.

Nora K Moog, Sonja Entringer, Jerod M Rasmussen, Martin Styner, John H Gilmore, Norbert Kathmann, Christine M Heim, Pathik D Wadhwa, Claudia Buss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 4 pooled it
21.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 4 syntheses or guidelines pooled it, 186 citations in OpenAlex.

  1. Pooled it
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  12. Maternal caregiving moderates relations between maternal childhood maltreatment and infant cortisol regulation.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Article
  13. Article
  14. Is neglect the first form of threat?Attachment & human development · 2025
    Review
  15. Review
  16. Article
  17. Article
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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Nora K MoogCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany; Institute of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Sonja EntringerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany; Development, Health, and Disease Research Program, University of California, Irvine, Irvine, California; Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, California.
Jerod M RasmussenDevelopment, Health, and Disease Research Program, University of California, Irvine, Irvine, California; Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, California.
Martin StynerDepartments of Psychiatry and Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
John H GilmoreDepartments of Psychiatry and Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Norbert KathmannBerlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany; Institute of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Christine M HeimCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany; Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, State College, Pennsylvania.
Pathik D WadhwaDevelopment, Health, and Disease Research Program, University of California, Irvine, Irvine, California; Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, California; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, California; Department of Obstetrics and Gynecology, School of Medicine, University of California, Irvine, Irvine, California; Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California.
Claudia BussCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany; Development, Health, and Disease Research Program, University of California, Irvine, Irvine, California; Department of Pediatrics, School of Medicine, University of California, Irvine, Irvine, California. Electronic address: claudia.buss@charite.de.
Humboldt-Universität zu Berlin · DEUniversity of California, Irvine · USUniversity of North Carolina at Chapel Hill · USFreie Universität Berlin · DEPennsylvania State University · US

Funding

Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUG3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI BARRETT, EMILY S, MILLER, RICHARD KERMIT · 2016 to 2024
$7.0M
Intergenerational Effects of Maternal Childhood Trauma on the Fetal BrainR01MH105538 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, FAIR, DAMIEN A · 2015 to 2019
$3.5M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3M
NICHD NIH HHS R01 HD060628NIH HHS UG3 OD023349NIMH NIH HHS R01 MH091351NIMH NIH HHS R01 MH105538
6 · The paper itself

Abstract

backgroundChildhood maltreatment (CM) confers deleterious long-term consequences, and growing evidence suggests some of these effects may be transmitted across generations. We examined the intergenerational effect of maternal CM exposure on child brain structure and also addressed the hypothesis that this effect may start during the child's intrauterine period of life.

methodsA prospective longitudinal study was conducted in a clinical convenience sample of 80 mother-child dyads. Maternal CM exposure was assessed using the Childhood Trauma Questionnaire. Structural magnetic resonance imaging was employed to characterize newborn global and regional brain (tissue) volumes near the time of birth.

resultsCM exposure was reported by 35% of the women. Maternal CM exposure was associated with lower child intracranial volume (F

conclusionsThese findings represent the first report to date associating maternal CM exposure with variation in newborn brain structure. These observations support our hypothesis of intergenerational transmission of the effects of maternal CM exposure on child brain development and suggest this effect may originate during the child's intrauterine period of life, which may have downstream neurodevelopmental consequences.

Indexed as

Adult Survivors of Child AbuseMaternal ExposureMother-Child RelationsAdultBrainFemaleHumansInfant, NewbornLongitudinal StudiesMagnetic Resonance ImagingMaleMothersOrgan SizePregnancyPrenatal Exposure Delayed EffectsProspective StudiesBrain developmentChildhood maltreatmentGray matter volumeIntergenerational transmissionNewbornPregnancy

Identifiers

PMID28842114
PMCPMC5723537
OpenAlexW2737148630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.