Evidence map›Paper›PMID 28841896›Full record

SynthesisCritical care (London, England)2017

A systematic review of diagnostic methods to differentiate acute lung injury/acute respiratory distress syndrome from cardiogenic pulmonary edema.

Kosaku Komiya, Tomohiro Akaba, Yuji Kozaki, Jun-Ichi Kadota, Bruce K Rubin

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Critical care (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 66 citations in OpenAlex.

  1. <p>Cigarette smoke combined withMolecular medicine reports · 2026
    Article
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  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. [Natriuretic peptides in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2023
    Review
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Endothelial TRPV4 channels in lung edema and injury.Current topics in membranes · 2022
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Radiologically and clinically diagnosed acute pulmonary oedema in critically ill patients: prevalence, patient characteristics, treatments and outcomes.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Kosaku KomiyaChildren's Hospital of Richmond at Virginia Commonwealth, Richmond, VA, 23298, USA. komiyakh1@oita-u.ac.jp.
Tomohiro AkabaChildren's Hospital of Richmond at Virginia Commonwealth, Richmond, VA, 23298, USA.
Yuji KozakiChildren's Hospital of Richmond at Virginia Commonwealth, Richmond, VA, 23298, USA.
Jun-Ichi KadotaRespiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan.
Bruce K RubinChildren's Hospital of Richmond at Virginia Commonwealth, Richmond, VA, 23298, USA.
Children's Hospital of Richmond at VCU · USOita University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiscriminating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) from cardiogenic pulmonary edema (CPE) is often challenging. This systematic review examines studies using biomarkers or images to distinguish ALI/ARDS from CPE.

methodsThree investigators independently identified studies designed to distinguish ALI/ARDS from CPE in adults. Studies were identified from PubMed, and the Cochrane Central Register of Controlled Trials database until July 3, 2017.

resultsOf 475 titles and abstracts screened, 38 full texts were selected for review, and we finally included 24 studies in this systematic review: 21 prospective observational studies, two retrospective observational studies, and one retrospective combined with prospective study. These studies compared various biomarkers to differentiate subjects with ALI/ARDS and in those with CPE, and 13 calculated the area under the receiver operator characteristic curve (AUC). The most commonly studied biomarker (four studies) was brain natriuretic peptide (BNP) and the discriminatory ability ranged from AUC 0.67-0.87 but the timing of measurement varied. Other potential biomarkers or tools have been reported, but only as single studies.

conclusionsThere were no identified biomarkers or tools with high-quality evidence for differentiating ALI/ARDS from CPE. Combining clinical criteria with validated biomarkers may improve the predictive accuracy.

Indexed as

Acute Lung InjuryBiomarkersDiagnosis, DifferentialHumansNatriuretic Peptide, BrainPulmonary EdemaRespiratory Distress SyndromeBiomarkersNatriuretic Peptide, BrainAcute respiratory failureBiomarkersHeart failurePulmonary edema

Identifiers

PMID28841896
PMCPMC6389074
OpenAlexW2747299546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.