Trial reportBMC infectious diseases2017
Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial.
Trial report in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Infection of neonates withMicrobiology spectrum · 2025Article
- Antimicrobial resistance ofVeterinary world · 2025Article
- Trachoma.Nature reviews. Disease primers · 2022Review
- Nasopharyngeal Carriage and Antimicrobial Susceptibility Profile ofPathogens (Basel, Switzerland) · 2021Article
- Impact of pneumococcal conjugate vaccine on the carriage density ofHuman vaccines & immunotherapeutics · 2020Article
- Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008-2015.Emerging infectious diseases · 2019Article
- Co-carriage ofClinical epidemiology and global healthArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundWe conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vaccinated), to determine the prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage.
methodsTwo hundred thirty-two children aged 5-10 years were recruited and followed from 4 to 20 months after vaccination started. We collected 1264 nasopharyngeal swabs (NPS). S. aureus was isolated following conventional microbiological methods. Risk factors for carriage were assessed by logistic regression.
resultsPrevalence of S. aureus carriage was 25.9%. In the univariable analysis, prevalence of S. aureus carriage was higher among children living in villages wholly-vaccinated with PCV-7 [OR = 1.57 95%CI (1.14 to 2.15)] and children with least 1 year of education [OR = 1.44 95%CI (1.07 to 1.92)]. S. aureus carriage was also higher during the rainy season [OR = 1.59 95%CI (1.20 to 2.11)]. Carriage of S. pneumoniae did not have any effect on S. aureus carriage for any pneumococcal, vaccine-type (VT) or non-vaccine-type (NVT) carriage. Multivariate analysis showed that the higher prevalence of S. aureus observed among children living in villages wholly-vaccinated with PCV-7 occurred only during the rainy season OR 2.72 95%CI (1.61-4.60) and not in the dry season OR 1.28 95%CI (0.78-2.09).
conclusionsPrevalence of nasopharyngeal carriage of S. aureus among Gambian children increased during the rainy season among those children living in PCV-7 wholly vaccinated communities. However, carriage of S. aureus is not associated with carriage of S. pneumoniae.
trial registrationISRCTN51695599 . Registered August 04th 2006.
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