Evidence map›Paper›PMID 28841830›Full record

ArticleNutrition journal2017

Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight.

Jeanett F Rohde, Lars Ängquist, Sofus C Larsen, Janne S Tolstrup, Lise Lotte N Husemoen, Allan Linneberg, Ulla Toft, Kim Overvad, Jytte Halkjær, Anne Tjønneland and 4 more

Abstract read
In one paragraph

Article in Nutrition journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jeanett F RohdeResearch Unit for Dietary Studies at the Parker Institute, Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Nordre Fasanvej 57, entrance 5, ground floor, 2000, Frederiksberg, Denmark. jeanett.friis.rohde@regionh.dk.
Lars ÄngquistDepartment of Clinical Epidemiology (Formerly 'Institute of Preventive Medicine'), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark.
Sofus C LarsenResearch Unit for Dietary Studies at the Parker Institute, Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Nordre Fasanvej 57, entrance 5, ground floor, 2000, Frederiksberg, Denmark.
Janne S TolstrupNational Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5 A, 1353, Copenhagen K, Denmark.
Lise Lotte N HusemoenResearch Centre for Prevention and Health, Capital Region of Denmark, Nordre Ringvej 57, building 84-85, 2600, Glostrup, Denmark.
Allan LinnebergResearch Centre for Prevention and Health, Capital Region of Denmark, Nordre Ringvej 57, building 84-85, 2600, Glostrup, Denmark.
Ulla ToftResearch Centre for Prevention and Health, Capital Region of Denmark, Nordre Ringvej 57, building 84-85, 2600, Glostrup, Denmark.
Kim OvervadSection for Epidemiology, Department of Public Health, Aarhus University, Nordre Ringgade 1, 8000, Aarhus C, Denmark.
Jytte HalkjærDanish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark.
Anne TjønnelandDanish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research (Section of Metabolic Genetics), and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Alle 20, 2200, Copenhagen N, Denmark.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research (Section of Metabolic Genetics), and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Alle 20, 2200, Copenhagen N, Denmark.
Thorkild I A SørensenDepartment of Clinical Epidemiology (Formerly 'Institute of Preventive Medicine'), Bispebjerg and Frederiksberg Hospital, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, first floor, 2000, Frederiksberg, Denmark.
Berit L HeitmannResearch Unit for Dietary Studies at the Parker Institute, Bispebjerg and Frederiksberg Hospital, the Capital Region, Copenhagen, Nordre Fasanvej 57, entrance 5, ground floor, 2000, Frederiksberg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have suggested a link between alcohol intake and adiposity. However, results from longitudinal studies have been inconsistent, and a possible interaction with genetic predisposition to adiposity measures has often not been taken into account.

objectiveTo examine the association between alcohol intake recorded at baseline and subsequent annual changes in body weight (∆BW), waist circumference (ΔWC) and WC adjusted for BMI (ΔWC

methodThis study included a total of 7028 adult men and women from MONICA, the Diet, Cancer and Health cohort (DCH), and the Inter99 studies. We combined 50 adiposity-associated SNPs into four scores indicating genetic predisposition to BMI, WC, WHR

resultsEach additional drink/day was associated with a ΔBW/year of -18.0 g (95% confidence interval (CI): -33.4, -2.6, P = 0.02) and a ΔWC of -0.3 mm/year (-0.5, -0.0, P = 0.03). In analyses of women only, alcohol intake was associated with a higher ΔWC

conclusionAlcohol intake was associated with a decrease in BW and WC among men and women, and an increase in WC

trial registrationRegistry: ClinicalTrials.gov Trial number: CT00289237 , Registered: 19 September 2005 retrospectively registered.

Indexed as

AdiposityAdultAlcohol DrinkingBody Mass IndexBody WeightCohort StudiesDietFemaleGenetic Predisposition to DiseaseHumansLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotideSex FactorsWaist CircumferenceAlcoholGene-diet interactionGenetic predispositionSNP scoreWaist changeWeight change

Identifiers

PMID28841830
PMCPMC5574083

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.