Evidence map›Paper›PMID 28841768›Full record

ArticleMicroscopy research and technique2017

Honeysuckle flowers extract loaded Bombyx mori silk fibroin films for inducing apoptosis of HeLa cells.

Chenlin Li, Mingying Yang, Liangjun Zhu, Yongqiang Zhu

Abstract read
In one paragraph

Article in Microscopy research and technique, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chenlin LiInstitute of Applied Bioresource, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310058, People's Republic of China.
Mingying YangInstitute of Applied Bioresource, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310058, People's Republic of China.
Liangjun ZhuInstitute of Applied Bioresource, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310058, People's Republic of China.
Yongqiang ZhuZhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang 310058, People's Republic of China.ORCID http://orcid.org/0000-0003-0734-0502

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to prepare silk fibroin (SF) films loaded with honeysuckle flowers extract (HFE) for inducing apoptosis of HeLa cells. We mixed solution of SF and HFE by air-drying for preparing the honeysuckle flowers extract loaded silk fibroin (SFH) films. The physical properties including morphologies, contact angle, roughness, and Z range were characterized. MTS assay and fluorescence micrographs proved that SFH films inhibited the proliferation rate of HeLa cells due to induction of HFE into SF films. Furthermore, cell apoptosis assay and cell cycle analysis confirmed that the apoptosis of HeLa cells resulted from SFH films. Therefore, SFH films designed in our study might be a promising candidate material for cancer therapy.

Indexed as

AnimalsApoptosisBiocompatible MaterialsBombyxCell ProliferationDrug Delivery SystemsFibroinsFlowersHeLa CellsHumansLoniceraMedicine, Chinese TraditionalNeoplasmsPlant ExtractsSilkBiocompatible MaterialsFibroinsPlant ExtractsSilkbiomaterialscancerChinese herbal medicine

Identifiers

PMID28841768
PMCPMC5763328

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.