Evidence map›Paper›PMID 28841758›Full record

ArticleNMR in biomedicine2017

Precision and accuracy of diffusion kurtosis estimation and the influence of b-value selection.

Andrey Chuhutin, Brian Hansen, Sune Nørhøj Jespersen

Abstract read
In one paragraph

Article in NMR in biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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  10. Surface-based Analyses of Diffusional Kurtosis Imaging in Amyotrophic Lateral Sclerosis: Relationship with Onset Subtypes.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
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  14. Efficient PCA denoising of spatially correlated redundant MRI data.Imaging neuroscience (Cambridge, Mass.) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrey ChuhutinCenter of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-9262-5101
Brian HansenCenter of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-6391-9407
Sune Nørhøj JespersenCenter of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-3146-4329

Funding

Development of MR Microscopy at the Cellular LevelR01EB012874 · NIBIB · UNIVERSITY OF FLORIDA · PI BLACKBAND, STEPHEN J. · 2010 to 2013
$2.1M
NIBIB NIH HHS R01 EB012874
6 · The paper itself

Abstract

Diffusion kurtosis imaging (DKI) is an extension of diffusion tensor imaging that accounts for leading non-Gaussian diffusion effects. In DKI studies, a wide range of different gradient strengths (b-values) is used, which is known to affect the estimated diffusivity and kurtosis parameters. Hence there is a need to assess the accuracy and precision of the estimated parameters as a function of b-value. This work examines the error in the estimation of mean of the kurtosis tensor (MKT) with respect to the ground truth, using simulations based on a biophysical model for both gray (GM) and white (WM) matter. Model parameters are derived from densely sampled experimental data acquired in ex vivo rat brain and in vivo human brain. Additionally, the variability of MKT is studied using the experimental data. Prevalent fitting protocols are implemented and investigated. The results show strong dependence on the maximum b-value of both net relative error and standard deviation of error for all of the employed fitting protocols. The choice of b-values with minimum MKT estimation error and standard deviation of error was found to depend on the protocol type and the tissue. Protocols that utilize two terms of the cumulant expansion (DKI) were found to achieve minimum error in GM at b-values less than 1 ms/μm

Indexed as

AnimalsDiffusion Tensor ImagingHumansRatsdiffusion methodsDiffusion weighted imagingmethods and engineeringmethods and engineering, Biophysical mechanisms of MR diffusionmethods and engineering, high order diffusion MR methods

Identifiers

PMID28841758
PMCPMC5715207

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.