Evidence map›Paper›PMID 28841701›Full record

ArticlePloS one2017

Pregnancy outcomes in perinatally HIV-infected young women in Madrid, Spain: 2000-2015.

Luis M Prieto, Carolina Fernández McPhee, Patricia Rojas, Diana Mazariegos, Eloy Muñoz, Maria José Mellado, África Holguín, María Luisa Navarro, María Isabel González-Tomé, José Tomás Ramos and 1 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Past and future of HIV infection. A document based on expert opinion.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Review
  5. Observational
  6. Review
  7. The next generation: Pregnancy in adolescents and women living with perinatally acquired HIV in South Africa.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Pregnancies in perinatally HIV-infected women: antiretroviral treatment strategies, obstetric and virologic outcomes.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Luis M PrietoPaediatrics Department, Hospital Universitario de Getafe, Madrid, Spain.ORCID http://orcid.org/0000-0001-8742-8752
Carolina Fernández McPheeInfectious Diseases Unit, Paediatrics Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Patricia RojasHIV-1 Molecular Epidemiology Laboratory, Microbiology and Parasitology Department, Hospital Ramón y Cajal-IRYCIS and CIBER-ESP, Madrid, Spain.
Diana MazariegosPaediatrics Department, Hospital Clínico Universitario San Carlos, Madrid, Spain.
Eloy MuñozObstetrics and Ginecology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Maria José MelladoTropical and Infectious Diseases Unit, Paediatrics Department, Hospital Universitario La Paz, Madrid, Spain.
África HolguínHIV-1 Molecular Epidemiology Laboratory, Microbiology and Parasitology Department, Hospital Ramón y Cajal-IRYCIS and CIBER-ESP, Madrid, Spain.
María Luisa NavarroInfectious Diseases Unit, Paediatrics Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
María Isabel González-ToméInfectious Diseases Unit, Paediatrics Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
José Tomás RamosPaediatrics Department, Hospital Clínico Universitario San Carlos, Madrid, Spain.
Madrid Cohort of HIV-Infected Mother-Infant Pairs
Hospital Clínico San Carlos · ESHospital General Universitario Gregorio Marañón · ESHospital Universitario 12 De Octubre · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESHospital Universitario de Getafe · ESHospital Universitario La Paz · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn increasing number of perinatally HIV-infected women (PHIV) are reaching adulthood and becoming pregnant. Most PHIV women have been exposed to a high number of antiretroviral regimens, and they may have difficulties to achieve viral suppression. Psychosocial problems are not uncommon and could be an important barrier for treatment adherence. The effects of chronic HIV infection and long-term exposure to antiretroviral treatment of PHIV women cause concerns on the developing fetus. The aims of this study were to describe the prevention of mother-to-child transmission strategies in PHIV women and the infant outcomes in the Madrid Cohort of HIV-infected mother-infant pairs.

methodsAll PHIV pregnant women registered in the Cohort that gave birth from 2000 to 2015 were included in the study.

resultsTwenty-eight pregnancies in twenty-two perinatally infected women were registered. Most women were Caucasian and heavily treatment-experienced. Nine cases (32.1%) were at high risk of HIV mother-to-child transmission. Maternal HIV-1 viral load was detectable close to delivery in four women (14.3%). The management of these cases was described, and the treatment strategies were discussed. None of the newborns acquired HIV infection. Eight infants (28.6%) were small for gestational age.

conclusionsThis study included a large series of pregnancies among PHIV women attended according to a youth-centered care model. The challenges in the management of this population by health-care providers were described. Specific strategies to minimize perinatal transmission risks should be addressed in future collaborative studies.

Indexed as

Pregnancy Complications, InfectiousPregnancy OutcomeAdolescentAdultAnti-HIV AgentsFemaleHIV InfectionsHumansPregnancySpainViral LoadYoung AdultAnti-HIV Agents

Identifiers

PMID28841701
PMCPMC5571961
OpenAlexW2748388095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.