ArticleJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society2018
Optic Disc Drusen in Children: The Copenhagen Child Cohort 2000 Eye Study.
Article in Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Association of optic disc drusen and small scleral canals - A systematic review and meta-analysis.Eye (London, England) · 2025Pooled it
- Optic disc drusen and scleral canal size - protocol for a systematic review and meta-analysis.Frontiers in ophthalmology · 2023Pooled it
- Optical coherence tomography measurement of retinal layers above the peripapillary hyperreflective ovoid mass-like structure in true papilloedema and pseudo-papilloedema.Eye (London, England) · 2026Article
- Optic Disc Flavoprotein Fluorescence Imaging as a Novel Method to Quantify Disease Burden in Optic Disc Drusen.American journal of ophthalmology · 2026Article
- Structural Damage, Visual Field Loss, and Quality of Life in Optic Disc Drusen: A Case-Control Study with Integrated Data-Driven Phenotypes.Journal of clinical medicine · 2025Article
- Applications of Optical Coherence Tomography in Optic Nerve Head Diseases: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Retinal peripapillary nerve fiber and retinal ganglion cell layer thickening preceed atrophy in children and teenagers with optic disc drusen.Scientific reports · 2025Observational
- Is the presence of peripapillary hyperreflective ovoid mass-like structures (PHOMS) in children related to the optic disc area, scleral canal diameter and refractive status?Eye (London, England) · 2025Article
- Prevalence Screening for Familial Optic Disc Drusen: A Cross-Sectional Study.Neuro-ophthalmology (Aeolus Press) · 2025Article
- Optic disc drusen: Dystrophic calcification, a potential target for treatment.Eye (London, England) · 2024Review
- Chiari Malformation Type I With Concurrent Bilateral Optic Disc Drusen: Is Follow-up Necessary?Cureus · 2024Article
- Macular retinal nerve fiber layer thickness in retinitis pigmentosa patients with and without optic disc drusen.Frontiers in ophthalmology · 2024Article
- Short-term progression of optic disc and macular changes in optic nerve head drusen.Eye (London, England) · 2023Observational
- Peripapillary hyper-reflective ovoid mass-like structures (PHOMS): clinical significance, associations, and prognostic implications in ophthalmic conditions.Frontiers in neurology · 2023Review
- Peripapillary hyperreflective ovoid mass-like structures: Multimodal imaging-A review.Clinical & experimental ophthalmology · 2023Review
- Volumetric Measurement of Peripapillary Hyperreflective Ovoid Masslike Structures in Patients with Optic Disc Drusen.Ophthalmology science · 2022Article
- Peripapillary Hyper-reflective Ovoid Mass-like Structure (PHOMS): An Optical Coherence Tomography Marker of Axoplasmic Stasis in the Optic Nerve Head.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2021Article
- Oxidative Stress in Optic Neuropathies.Antioxidants (Basel, Switzerland) · 2021Review
- OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH).Life (Basel, Switzerland) · 2021Article
- Optic disc drusen mimicking Idiopathic Intracranial Hypertension (IIH): rely on ultrasound.Neurological research and practice · 2021Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptic disc drusen (ODD) are seen in up to 2.4% of the general population, but the etiology and pathophysiology of the condition is still unknown. The purpose of this study was to determine the prevalence of ODD in a population-based child cohort and to determine if scleral canal diameter and fetal birth and pubertal parameters are associated with the presence of ODD.
methodsThis observational, longitudinal population-based birth cohort study, with a nested case-control, included 1,406 children. Eye examinations were performed when the children were between 11 and 12 years of age. Assessment was performed of optical coherence tomography (OCT) scans from 1,304 children with gradable enhanced depth imaging scans of the optic disc.
resultsODD in one or both eyes were found in 13 (1.0%) of all children. All but one of the cases were found in children with scleral canal diameter in the lowest quartile (1,182-1,399 μm) in the nested case-control study. Children with ODD had a mean disc diameter of 1,339 μm (interquartile range, 30 μm), whereas it was 1,508 μm (interquartile range, 196 μm) in the 130 controls without ODD (P < 0.001). No differences in sex, birth weight, refractive error, and Tanner stages (of puberty) were found between children with and without ODD.
conclusionsThe prevalence of ODD was 1% in a large child cohort examined by OCT. ODD was found only in eyes with a narrow scleral canal, which is consistent with the hypothesis that ODD might arise as a consequence of retinal nerve fiber congestion in the scleral canal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.