ArticleDrug and alcohol dependence2017
Adverse childhood experience effects on opioid use initiation, injection drug use, and overdose among persons with opioid use disorder.
Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 97 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventing Opioid Use Among Justice-involved Youth as They Transition to Adulthood: Leveraging Safe Adults (LeSA)
Green Light Therapy As a Non-Pharmacologic Intervention to Decrease Anxiety in Pregnant Women With Opioid Use Disorder
ACE, Resilience, and Substance Use Disorder: Maternal and Baby Outcomes in the First Year of Life
Who cites it
97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review.British journal of anaesthesia · 2025Pooled it
- Prevalence of childhood maltreatment among people with opioid use disorder: A systematic review and meta-analysis.Drug and alcohol dependence · 2021Pooled it
- Preventing opioid use among justice-involved youth as they transition to adulthood: leveraging safe adults (LeSA).BMC public health · 2021Trial
- The association between elder abuse and childhood adversity: A study of older adults in Malaysia.PloS one · 2021Trial
- Trial
- What We Owe: A Liberatory Ethics of Harm Reduction.Nursing inquiry · 2026Article
- Early Adverse Experiences and the Likelihood of Substance Use Disorders and Non-Fatal Overdose in Clinical and Community Settings: A Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2026Review
- Evaluating the Combined Effects of an Adverse Childhood Experiences-Focused Family Advocate Model and the Strengthening Families Program: Study Protocol for a Hybrid Type 1 Effectiveness-Implementation Trial in 36 New Jersey Communities.JMIR research protocols · 2026Article
- Drug-Induced Deaths and Non-Fatal Poisonings in Youth-Associations With Household Adversities and Out-Of-Home Care.Drug and alcohol review · 2026Article
- Assessing behavioural economic demand for morphine after an acute dose in individuals with- and without childhood trauma: a double-blind, randomised, controlled trial.Psychopharmacology · 2025Article
- Childhood trauma and adolescent substance use: an integrative perspective.Future science OA · 2025Article
- When Mothers and Fathers Are 'Gone': Predicting Intergenerational Cycles of Risk in Opioid-Involved Parents.Children (Basel, Switzerland) · 2025Article
- Chronic adolescent stress attenuates morphine-induced antinociception and central amygdala neuronal activation in adult Wistar rats.Physiology & behavior · 2025Article
- Clinicians' attitudes and knowledge of medicinal cannabis in opioid dependence treatment clinics in New South Wales, Australia.Journal of cannabis research · 2025Article
- Which social media platforms facilitate monitoring the opioid crisis?PLOS digital health · 2025Article
- Association Between Self-Reported Opioid Use and Behavioral/Social Health Characteristics-Arizona, 2020.International journal of mental health and addiction · 2025Article
- Risk Factors and Onset of Illicit Drug Use among Filipino Youth: A Cross-sectional Analysis of Sociodemographic and Environmental Influences.Acta medica Philippina · 2025Article
- Increased risk of non-fatal overdose associated with broad adverse childhood experiences among people who use drugs in New York City: a latent class analysis.The American journal of drug and alcohol abuse · 2025Article
- Modulating mechanisms of adverse childhood experiences in a mindfulness-based intervention: preliminary insights from an opioid use disorder study.Frontiers in psychology · 2025Article
- Adolescents' Adverse Childhood Experiences, Poor Mental Health, and Substance Use During the COVID-19 Pandemic.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionAdverse childhood experiences are associated with the development of substance use disorders. With opioid use disorder, a growing concern in the United States, we were interested in examining the relationship between adverse experiences and three landmarks of opioid use: age of opioid initiation, injection drug use, and lifetime overdose.
methodsBetween May and December 2015, we interviewed consecutive persons seeking inpatient opioid detoxification. Participants were asked about age of opioid initiation, last month injection drug use, and lifetime history of overdose, and completed the ten-item Adverse Childhood Experience (ACE) questionnaire.
resultsParticipants (n=457) averaged 32.2 (±8.64) years of age, 71.3% were male, and 82.5% were non-Hispanic White. The mean score on the ACE scale was 3.64 (±2.75). Mean age at time of initiating opioid use was 21.7 (±7.1) years, 68.7% had injected drugs within the past month, and 39.0% had overdosed. After adjusting for age, gender, and ethnicity, the ACE score was inversely associated with age of initiating opioid use (b=-0.50, 95% CI -0.70; -0.29, p<.001), and positively associated with recent injection drug use (OR=1.11, 95% CI 1.02; 1.20, p=0.014) and the likelihood of experiencing an overdose (OR=1.10, 95% CI 1.02; 1.20, p=0.015) in a graded dose response manner.
conclusionGreater adverse childhood experiences are associated with three landmarks of opioid use risk. ACE screening may be useful in identifying high-risk subsets of opioid-using populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.