ArticleJournal of the American Chemical Society2017
Facile Assembly/Disassembly of DNA Nanostructures Anchored on Cell-Mimicking Giant Vesicles.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Spatio-Temporal Processes of Diffusion-Controlled Communication in Hierarchical Multi-Compartments.Angewandte Chemie (International ed. in English) · 2025Article
- Outward Movement of Targeting Ligands from a Built-In Reserve Pool in Nuclease-Resistant 3D Hierarchical DNA Nanocluster for in Vivo High-Precision Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- The biological applications of DNA nanomaterials: current challenges and future directions.Signal transduction and targeted therapy · 2021Review
- DNA nanostructure-based nucleic acid probes: construction and biological applications.Chemical science · 2021Review
- Lipid-oligonucleotide conjugates for bioapplications.National science review · 2020Article
- DNA-based artificial molecular signaling system that mimics basic elements of reception and response.Nature communications · 2020Article
- DNA nanotweezers for stabilizing and dynamically lighting up a lipid raft on living cell membranes and the activation of T cells.Chemical science · 2020Article
- Protocells programmed through artificial reaction networks.Chemical science · 2019Review
- Gold Nanocluster-Mediated Efficient Delivery of Cas9 Protein through pH-Induced Assembly-Disassembly for Inactivation of Virus Oncogenes.ACS applied materials & interfaces · 2019Article
- Bioapplications of DNA nanotechnology at the solid-liquid interface.Chemical Society reviews · 2019Review
- Design and fabrication of flexible DNA polymer cocoons to encapsulate live cells.Nature communications · 2019Article
- Artificial Signal Feedback Network Mimicking Cellular Adaptivity.Journal of the American Chemical Society · 2019Article
- Dynamic Interactions between Lipid-Tethered DNA and Phospholipid Membranes.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Engineering a 3D DNA-Logic Gate Nanomachine for Bispecific Recognition and Computing on Target Cell Surfaces.Journal of the American Chemical Society · 2018Article
- Constructing Smart Protocells with Built-In DNA Computational Core to Eliminate Exogenous Challenge.Journal of the American Chemical Society · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
DNA nanostructures assembled on living cell membranes have become powerful research tools. Synthetic lipid membranes have been used as a membrane model to study the dynamic behavior of DNA nanostructures on fluid soft lipid bilayers, but without the inherent complexity of natural membranes. Herein, we report the assembly and disassembly of DNA nanoprisms on cell-mimicking micrometer-scale giant membrane vesicles derived from living mammalian cells. Three-dimensional DNA nanoprisms with a DNA arm and a cholesterol anchor were efficiently localized on the membrane surface. The assembly and disassembly of DNA nanoprisms were dynamically manipulated by DNA strand hybridization and toehold-mediated strand displacement. Furthermore, the heterogeneity of reversible assembly/disassembly of DNA nanoprisms was monitored by Förster resonance energy transfer. This study suggests the feasibility of DNA-mediated functional biomolecular assembly on cell membranes for biomimetics studies and delivery systems.
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Registered trials
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