Evidence map›Paper›PMID 28841225›Full record

ArticleCancer2017

Long-term weight loss after colorectal cancer diagnosis is associated with lower survival: The Colon Cancer Family Registry.

Jonathan M Kocarnik, Xinwei Hua, Sheetal Hardikar, Jamaica Robinson, Noralane M Lindor, Aung Ko Win, John L Hopper, Jane C Figueiredo, John D Potter, Peter T Campbell and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Jonathan M KocarnikPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID http://orcid.org/0000-0001-8084-1608
Xinwei HuaPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Sheetal HardikarPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Jamaica RobinsonPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Noralane M LindorDepartment of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona.
Aung Ko WinMelbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
John L HopperMelbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Jane C FigueiredoDepartment of Preventive Medicine, University of Southern California, Los Angeles, California.ORCID http://orcid.org/0000-0002-2452-3194
John D PotterPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Peter T CampbellEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Steven GallingerPrevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.
Michelle CotterchioPrevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.
Scott V AdamsDepartment of Medicine, University of Washington, Seattle, Washington.
Stacey A CohenDivision of Oncology, University of Washington, Seattle, Washington.
Amanda I PhippsPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Polly A NewcombPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID http://orcid.org/0000-0001-8786-0043
Fred Hutch Cancer Center · USUniversity of Washington · USCancer Care Ontario · CAThe University of Melbourne · AUAmerican Cancer Society · USMayo Clinic in Arizona · USUniversity of Southern California · US

Funding

NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
SEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1M
Institute of Translational Health SciencesKL2TR000421 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$12.6M
ONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5M
Colon Cancer Family Registry CohortUM1CA167551 · NCI · STANFORD UNIVERSITY · PI HAILE, ROBERT WILLIAM, JENKINS, MARK A · 2013 to 2017
$11.3M
FAMILIAL COLORECTAL NEOPLASIA COLLABORATIVE GROUPU01CA074800 · NCI · MAYO CLINIC ROCHESTER · PI LINDOR, NORALANE MOREY · 1997 to 2007
$9.1M
The Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0M
AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRYU01CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2002 to 2007
$6.9M
The Colon Cancer Family Registry: AustralasiaU24CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2008 to 2011
$6.2M
The Familial Colorectal Neoplasia Collaborative GroupU24CA074800 · NCI · MAYO CLINIC ROCHESTER · PI LINDOR, NORALANE MOREY, THIBODEAU, STEPHEN NORMAN · 2008 to 2011
$5.3M
The Colon Cancer Family Registry: OntarioU24CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 2008 to 2011
$4.1M
Contributing Factors and Consequences of Cancer Health DisparitiesT32CA094880 · NCI · UNIVERSITY OF WASHINGTON · PI Christopher I Li, AMANDA IRENE PHIPPS · 2017 to 2026
$3.7M
CCR NIH HHS HHSN261201300011CNCATS NIH HHS KL2 TR000421NCATS NIH HHS KL2 TR002317NCI NIH HHS HHSN261201000121CNCI NIH HHS HHSN261201300012INCI NIH HHS HHSN261201300021CNCI NIH HHS K05 CA152715NCI NIH HHS K07 CA172298NCI NIH HHS N01 CN067009NCI NIH HHS N01 PC035142NCI NIH HHS T32 CA094880NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA097735NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551NHGRI NIH HHS L30 HG009290
6 · The paper itself

Abstract

backgroundBody weight is associated with colorectal cancer (CRC) risk and survival, but to the authors' knowledge, the impact of long-term postdiagnostic weight change is unclear. Herein, the authors investigated whether weight change over the 5 years after a diagnosis of CRC is associated with survival.

methodsCRC cases diagnosed from 1997 to 2008 were identified through 4 population-based cancer registry sites. Participants enrolled within 2 years of diagnosis and reported their height and weight 2 years prior. Follow-up questionnaires were administered approximately 5 years after diagnosis. Associations between change in weight (in kg) or body mass index (BMI) with overall and CRC-specific survival were estimated using Cox regression analysis adjusted for age, sex, American Joint Committee on Cancer stage of disease, baseline BMI, nonsteroidal anti-inflammatory drug use, smoking, time between diagnosis and enrollment, and study site.

resultsAt the 5-year postdiagnostic survey, 2049 participants reported higher (53%; median plus 5 kg), unchanged (12%), or lower (35%; median -4 kg) weight. Over a median of 5.1 years of subsequent follow-up (range, 0.3-9.9 years), 344 participants died (91 of CRC). Long-term weight loss (per 5 kg) was found to be associated with poorer overall survival (hazard ratio, 1.13; 95% confidence interval, 1.07-1.21) and CRC-specific survival (hazard ratio, 1.25; 95% confidence interval, 1.13-1.39). Significantly lower survival was similarly observed for relative weight loss (>5% vs ≤5% change), BMI reduction (per 1 unit), or BMI category change (overweight to normal vs remaining overweight).

conclusionsWeight loss 5 years after a diagnosis of CRC was found to be significantly associated with decreased long-term survival, suggesting the importance of avoiding weight loss in survivors of CRC. Future research should attempt to further evaluate this association, accounting for whether this weight change was intentional or represents a marker of declining health. Cancer 2017;123:4701-4708. © 2017 American Cancer Society.

Indexed as

Cancer SurvivorsWeight LossBody Mass IndexColorectal NeoplasmsFemaleHumansMaleMiddle AgedPrognosisRegistriesRisk FactorsSurvival Ratebody mass index (BMI)colorectal neoplasmsepidemiologyfollow-up studiesmortalitysurvivorsweight loss

Identifiers

PMID28841225
PMCPMC5693760
OpenAlexW2749435886

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.