Evidence map›Paper›PMID 28841133›Full record

ArticleeLife2017

Transcription factor clusters regulate genes in eukaryotic cells.

Adam Jm Wollman, Sviatlana Shashkova, Erik G Hedlund, Rosmarie Friemann, Stefan Hohmann, Mark C Leake

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 105 citations in OpenAlex.

  1. Glucose repression ofbioRxiv : the preprint server for biology · 2026
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  13. Individual transcription factors modulate both the micromovement of chromatin and its long-range structure.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Adam Jm Wollman *Biological Physical Sciences Institute, University of York, York, United Kingdom.ORCID http://orcid.org/0000-0002-5501-8131
Sviatlana Shashkova *Biological Physical Sciences Institute, University of York, York, United Kingdom.ORCID https://orcid.org/0000-0002-4641-3295
Erik G HedlundBiological Physical Sciences Institute, University of York, York, United Kingdom.
Rosmarie FriemannDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Stefan HohmannDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Mark C LeakeBiological Physical Sciences Institute, University of York, York, United Kingdom.ORCID http://orcid.org/0000-0002-1715-1249
University of York · GBChalmers University of Technology · SEUniversity of Gothenburg · SE

Funding

Biotechnology and Biological Sciences Research Council BB/N006453/1Medical Research Council MR/K01580X/1
6 · The paper itself

Abstract

Transcription is regulated through binding factors to gene promoters to activate or repress expression, however, the mechanisms by which factors find targets remain unclear. Using single-molecule fluorescence microscopy, we determined in vivo stoichiometry and spatiotemporal dynamics of a GFP tagged repressor, Mig1, from a paradigm signaling pathway of

Indexed as

Gene Expression Regulation, FungalTranscription, GeneticGenes, ReporterGreen Fluorescent ProteinsModels, BiologicalProtein BindingProtein TransportRecombinant Fusion ProteinsRepressor ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSingle Molecule ImagingSpatio-Temporal AnalysisStaining and LabelingGreen Fluorescent ProteinsMIG1 protein, S cerevisiaeRecombinant Fusion ProteinsRepressor ProteinsSaccharomyces cerevisiae Proteinsbiophysicscell signalingchromosomesgene expressiongenesS. cerevisiaesingle-moleculestructural biologysuper-resolutiontranscription factors

Identifiers

PMID28841133
PMCPMC5602325
OpenAlexW2606029542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.