ArticleAnnals of laboratory medicine2017
Comparison of Traditional and Reverse Syphilis Screening Algorithms in Medical Health Checkups.
Article in Annals of laboratory medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Comparative performance of the traditional and reverse diagnostic algorithms for syphilis in pregnancy.Pregnancy (Hoboken, N.J.) · 2026Article
- Penile mass with a past: Tertiary syphilis presenting as a penile gumma.Urology case reports · 2026Article
- Diagnostic performance ofSexually transmitted infections · 2025Article
- British Columbia's Experience after Implementation of the Treponema pallidum Reverse Algorithm and PCR Detection, 2015 to 2020.Microbiology spectrum · 2022Article
- STI prevalence among men living with HIV engaged in safer conception care in rural, southwestern Uganda.PloS one · 2021Article
- Comparison and evaluation of Abbott chemiluminescent microparticle immunoassay and ChIVD light-initiated chemiluminescent assay in the detection of Treponema pallidum antibody.Journal of clinical laboratory analysis · 2020Article
- The Multi-Institutional Health Screening Records Database of South Korea: Description and Evaluation of Its Characteristics.Yonsei medical journal · 2019Article
- Urea-mediated dissociation alleviate the false-positive Treponema pallidum-specific antibodies detected by ELISA.PloS one · 2019Article
- A Model for Syphilis Screening in the Emergency Department.Public health reports (Washington, D.C. : 1974)Article
- Traditional versus reverse algorithm for diagnosis of syphilis - An Indian perspective from a national referral laboratory for sexually transmitted infections.Indian journal of sexually transmitted diseases and AIDSArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe syphilis diagnostic algorithms applied in different countries vary significantly depending on the local syphilis epidemiology and other considerations, including the expected workload, the need for automation in the laboratory and budget factors. This study was performed to investigate the efficacy of traditional and reverse syphilis diagnostic algorithms during general health checkups.
methodsIn total, 1,000 blood specimens were obtained from 908 men and 92 women during their regular health checkups. Traditional screening and reverse screening were applied to the same specimens using automatic rapid plasma regain (RPR) and Treponema pallidum latex agglutination (TPLA) tests, respectively. Specimens that were reverse algorithm (TPLA) reactive, were subjected to a second treponemal test performed by using the chemiluminescent microparticle immunoassay (CMIA).
resultsOf the 1,000 specimens tested, 68 (6.8%) were reactive by reverse screening (TPLA) compared with 11 (1.1%) by traditional screening (RPR). The traditional algorithm failed to detect 48 specimens [TPLA(+)/RPR(-)/CMIA(+)]. The median TPLA cutoff index (COI) was higher in CMIA-reactive cases than in CMIA-nonreactive cases (90.5 vs 12.5 U).
conclusionsThe reverse screening algorithm could detect the subjects with possible latent syphilis who were not detected by the traditional algorithm. Those individuals could be provided with opportunities for evaluating syphilis during their health checkups. The COI values of the initial TPLA test may be helpful in excluding false-positive TPLA test results in the reverse algorithm.
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