ReviewAnnals of laboratory medicine2017
Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry in Clinical Microbiology: What Are the Current Issues?
Review in Annals of laboratory medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed.
- Rapid Screening of Methicillin-ResistantAnalytical chemistry · 2025Trial
- Comparison of Bruker Biotyper Sirius, VITEK MS PRIME, and ASTA MicroIDSys MALDI-TOF MS Systems forAnnals of laboratory medicine · 2026Article
- Intra-amniotic infection: diagnosis, nomenclature, clinical significance, management, and microbiologic tools used for the diagnosis.Clinical microbiology reviews · 2026Review
- Comparative analytical performance of Autof MS2600 and Biotyper Sirius for rapid MALDI-TOF MS identification of microorganisms from positive blood cultures.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Enhanced classification and identification of bacterial and viral microorganisms by integration of MALDI-TOF mass spectrometry with artificial intelligence.Scientific reports · 2026Article
- A Review on the Current and Future State of Urinary Tract Infection Diagnostics.International journal of molecular sciences · 2025Review
- Scanning electron microscopy and extended viability testing as a tool to evaluate the safety of MALDI-TOF extracts for risk group 3 spore-forming bacteria.Journal of medical microbiology · 2025Article
- Toxic Shock Syndrome Toxin-1 (TSST-1) inToxins · 2025Review
- Pulmonary Mycobacterium heckeshornense Infection in which the Causative Microorganism Was Difficult to Identify.Internal medicine (Tokyo, Japan) · 2025Article
- Identification of Legionella by MALDI Biotyper through three preparation methods and an in-house library comparing phylogenetic and hierarchical cluster results.Scientific reports · 2025Article
- Bacterial identification using MALDI-TOF mass spectrometry in positive blood cultures: A pilot study.Journal of biological methods · 2025Article
- Identification of environmental Actinobacteria in buildings by means of chemotaxonomy, 16S rRNA sequencing, and MALDI-TOF MS.Microbiology spectrum · 2024Article
- Ultra-Fast Impedimetric Immunoassay for Detection ofMicromachines · 2023Article
- Characterization of the salivary microbiome before and after antibiotic therapy via separation technique.Applied microbiology and biotechnology · 2023Article
- Occurrence ofFoods (Basel, Switzerland) · 2023Article
- Peptide Mass Spectra from Micrometer-Thick Ice Films Produced with Femtosecond Pulses.Analytical chemistry · 2022Article
- Performance of a Machine Learning-Based Methicillin Resistance ofMicroorganisms · 2022Article
- Validation of the Colibrí Instrument for Automated Preparation of MALDI-TOF MS Targets for Yeast Identification.Journal of clinical microbiology · 2022Article
- Pseudomonas species prevalence, protein analysis, and antibiotic resistance: an evolving public health challenge.AMB Express · 2022Article
- Large-Scale Samples Based Rapid Detection of Ciprofloxacin Resistance inFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized the identification of microbial species in clinical microbiology laboratories. MALDI-TOF-MS has swiftly become the new gold-standard method owing to its key advantages of simplicity and robustness. However, as with all new methods, adoption of the MALDI-TOF MS approach is still not widespread. Optimal sample preparation has not yet been achieved for several applications, and there are continuing discussions on the need for improved database quality and the inclusion of additional microbial species. New applications such as in the field of antimicrobial susceptibility testing have been proposed but not yet translated to the level of ease and reproducibility that one should expect in routine diagnostic systems. Finally, during routine identification testing, unexpected results are regularly obtained, and the best methods for transmitting these results into clinical care are still evolving. We here discuss the success of MALDI-TOF MS in clinical microbiology and highlight fields of application that are still amenable to improvement.
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