Evidence map›Paper›PMID 28840473›Full record

ArticleMolecular neurobiology2018

DREAM-Dependent Activation of Astrocytes in Amyotrophic Lateral Sclerosis.

Pilar Larrodé, Ana Cristina Calvo, Laura Moreno-Martínez, Miriam de la Torre, Leticia Moreno-García, Nora Molina, Tomás Castiella, Cristina Iñiguez, Luis Fernando Pascual, Francisco Javier Miana Mena and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. KCells · 2023
    Review
  5. Emerging Role of DREAM in Healthy Brain and Neurological Diseases.International journal of molecular sciences · 2023
    Review
  6. Function of Glia in Aging and the Brain Diseases.International journal of medical sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pilar LarrodéService of Neurology, University Clinical Hospital, Avda. San Juan Bosco, 15, Zaragoza, 50009, Spain.
Ana Cristina CalvoLAGENBIO (Laboratory of Genetics and Biochemistry), Faculty of Veterinary-IIS, IA2-CITA, University of Zaragoza, Miguel Servet 177, 50013, Zaragoza, Spain. accalvo@unizar.es.
Laura Moreno-MartínezLAGENBIO (Laboratory of Genetics and Biochemistry), Faculty of Veterinary-IIS, IA2-CITA, University of Zaragoza, Miguel Servet 177, 50013, Zaragoza, Spain.
Miriam de la TorreLAGENBIO (Laboratory of Genetics and Biochemistry), Faculty of Veterinary-IIS, IA2-CITA, University of Zaragoza, Miguel Servet 177, 50013, Zaragoza, Spain.
Leticia Moreno-GarcíaLAGENBIO (Laboratory of Genetics and Biochemistry), Faculty of Veterinary-IIS, IA2-CITA, University of Zaragoza, Miguel Servet 177, 50013, Zaragoza, Spain.
Nora MolinaLAGENBIO (Laboratory of Genetics and Biochemistry), Faculty of Veterinary-IIS, IA2-CITA, University of Zaragoza, Miguel Servet 177, 50013, Zaragoza, Spain.
Tomás CastiellaService of Anatomic Pathology, University Clinical Hospital, Avda. San Juan Bosco, 15, Zaragoza, 50009, Spain.
Cristina IñiguezService of Neurology, University Clinical Hospital, Avda. San Juan Bosco, 15, Zaragoza, 50009, Spain.
Luis Fernando PascualService of Neurology, University Clinical Hospital, Avda. San Juan Bosco, 15, Zaragoza, 50009, Spain.
Francisco Javier Miana MenaDepartment of Physiology, Faculty of Medicine, University of Zaragoza, C/ Domingo Miral s/n, Zaragoza, 50009, Spain.
Pilar ZaragozaLAGENBIO (Laboratory of Genetics and Biochemistry), Faculty of Veterinary-IIS, IA2-CITA, University of Zaragoza, Miguel Servet 177, 50013, Zaragoza, Spain.
Santiago Ramón Y CajalService of Anatomic Pathology, University Clinical Hospital, Avda. San Juan Bosco, 15, Zaragoza, 50009, Spain.
Rosario OstaLAGENBIO (Laboratory of Genetics and Biochemistry), Faculty of Veterinary-IIS, IA2-CITA, University of Zaragoza, Miguel Servet 177, 50013, Zaragoza, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of unknown origin and characterized by a relentless loss of motor neurons that causes a progressive muscle weakness until death. Among the several pathogenic mechanisms that have been related to ALS, a dysregulation of calcium-buffering proteins in motor neurons of the brain and spinal cord can make these neurons more vulnerable to disease progression. Downstream regulatory element antagonist modulator (DREAM) is a neuronal calcium-binding protein that plays multiple roles in the nucleus and cytosol. The main aim of this study was focused on the characterization of DREAM and glial fibrillary acid protein (GFAP) in the brain and spinal cord tissues from transgenic SOD1

Indexed as

AgedAmyotrophic Lateral SclerosisAnimalsAstrocytesDisease Models, AnimalDisease ProgressionHumansKv Channel-Interacting ProteinsMaleMiceMice, TransgenicMiddle AgedMotor NeuronsRepressor ProteinsSpinal CordUp-RegulationCsen protein, mouseKv Channel-Interacting ProteinsRepressor ProteinsALSAstrocyteCalciumDREAMMotor neuron diseaseNeurodegeneration

Identifiers

PMID28840473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.