Evidence map›Paper›PMID 28840395›Full record

ArticleDigestive diseases and sciences2017

Clopidogrel IBS Patients Have Higher Incidence of Gastrointestinal Symptoms Influenced by Age and Gender.

Suren Soghomonyan, Mahmoud Abdel-Rasoul, Alix Zuleta-Alarcon, Iveta Grants, Victor Davila, Jeffrey Yu, Cheng Zhang, Emmett E Whitaker, Sergio D Bergese, Nicoleta Stoicea and 2 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Suren SoghomonyanDepartment of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA.
Mahmoud Abdel-RasoulDepartment of Biomedical Informatics, Center for Biostatistics, The Ohio State University, 1800 Cannon Drive, Room 320, Columbus, OH, 43210, USA.
Alix Zuleta-AlarconDepartment of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA.
Iveta GrantsDepartment of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA.
Victor DavilaDepartment of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA.
Jeffrey YuDepartment of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA.
Cheng ZhangDepartment of Internal Medicine, Wexner Medical Center, The Ohio State University, 395 West 12th Ave, Suite 200, Columbus, OH, 43210, USA.
Emmett E WhitakerDepartment of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA.
Sergio D BergeseDepartment of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA.
Nicoleta StoiceaDepartment of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA.
Razvan ArsenescuDepartment of Internal Medicine, Wexner Medical Center, The Ohio State University, 395 West 12th Ave, Suite 200, Columbus, OH, 43210, USA.
Fievos L ChristofiDepartment of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA. Fedias.Christofi@osumc.edu.ORCID 0000-0003-2773-6846
The Ohio State University Wexner Medical Center · USNationwide Children's Hospital · USThe Ohio State University · US

Funding

Neuroimaging of Purinergic Pathways in the Human ENSR01DK093499 · NIDDK · OHIO STATE UNIVERSITY · PI CHRISTOFI, FEDIAS LEONTIOU · 2012 to 2015
$1.3M
Mark I Model 68A Rodent/Cell line Gamma IrradiatorS10RR019134 · NCRR · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI FELDMAN, SANFORD H · 2004 to 2004
$358k
NCRR NIH HHS S10 RR019134NIDDK NIH HHS R01 DK093499
6 · The paper itself

Abstract

backgroundClopidogrel is an irreversible antagonist of P2Y

aimTo evaluate if blockade of P2Y

methodsA retrospective analysis of our institutional database was conducted for a 13-year period. IBS patients were identified, and their demographics, GI symptoms and clopidogrel therapy were collected. Logistic regression models were used to characterize symptoms in clopidogrel versus no-clopidogrel IBS-groups, adjusting for Age and Sex differences. An additional study characterized the P2Y

resultsThe search identified 7217 IBS patients (6761 no-clopidogrel/456 clopidogrel). There were a higher proportion of patients with GI symptoms on clopidogrel (68%) compared to controls (60%, p = 0.0011) that were Females (70 vs. 60%, p = 0.0003) not Males (61 vs. 60%; p = 0.8312). In Females, clopidogrel was associated with higher incidence of GI symptoms (Age adjusted; p < 0.0001) for pain, constipation, gastroparesis (p ≤ 0.0001) and psychogenic pain (p = 0.0006). Age or Sex (adjusted models) influenced one or more GI symptoms (i.e., pain, p < 0.0001; constipation, p < 0.0001/p = 0.008; diarrhea, flatulence, p = 0.01). P2Y

conclusionsIrreversible blockade of P2Y

Indexed as

Abdominal PainAdolescentAdultAgedAge FactorsClopidogrelConstipationDatabases, FactualDiarrheaElectronic Health RecordsEnteric Nervous SystemFemaleFlatulenceGastroparesisHumansIncidenceClopidogrelP2RY12 protein, humanPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y12TiclopidineAbdominal painAgeClopidogrelConstipationDiarrheaEnteric glial cellsEnteric nervous systemFlatulenceGastroparesisGenderIrritable bowel syndromeP2Y12 receptors

Identifiers

PMID28840395
PMCPMC6075816
OpenAlexW2745780179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.