Evidence map›Paper›PMID 28840198›Full record

ArticleChronic stress (Thousand Oaks, Calif.)2017

Biobehavioral Mechanisms of Mindfulness as a Treatment for Chronic Stress: An RDoC Perspective.

Eric L Garland, Adam W Hanley, Anne K Baker, Matthew O Howard

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chronic stress (Thousand Oaks, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05659472 (The Effect of Combination Mindfulness Spiritual-Based Cognitive Therapy Plus Hypnosis on Levels of Cortisol, Serotonin, and Depression Degree in HIV Patients With Depression), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05659472 nacompletednot on this mapstarted 2020, after this paper: background citation

The Effect of Combination Mindfulness Spiritual-Based Cognitive Therapy Plus Hypnosis on Levels of Cortisol, Serotonin, and Depression Degree in HIV Patients With Depression

TypeinterventionalSponsorHealth Technology Institute of Cendekia Utama KudusRan2020 to 2021Enrolled62ConditionsDepressionArmsCombination mindfulness spiritual-based cognitive therapy plus hypnosis, Mindfulness-based cognitive therapy
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

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  8. Effects of a Smartphone-Based Mindfulness Intervention on Momentary Stress Among First Responders: a Micro-Randomized Trial.Prevention science : the official journal of the Society for Prevention Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Eric L GarlandCenter on Mindfulness and Integrative Health Intervention Development (C-MIIND) College of Social Work, University of Utah, Salt Lake City, UT, USA.
Adam W HanleyCenter on Mindfulness and Integrative Health Intervention Development (C-MIIND) College of Social Work, University of Utah, Salt Lake City, UT, USA.
Anne K BakerCenter on Mindfulness and Integrative Health Intervention Development (C-MIIND) College of Social Work, University of Utah, Salt Lake City, UT, USA.
Matthew O HowardSchool of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of Utah · USUniversity of North Carolina at Chapel Hill · US

Funding

Targeting Hedonic Dysregulation to Address Chronic Pain and Opioid Misuse in Primary Care.R01DA042033 · NIDA · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE · 2016 to 2020
$2.8M
Effects of Mindfulness-Oriented Intervention on Endogenous Opioid Mechanisms of Hedonic Regulation in Chronic Pain.R61AT009296 · NCCIH · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE, ZUBIETA, JON-KAR · 2016 to 2017
$831k
NCCIH NIH HHS R61 AT009296NIDA NIH HHS R01 DA042033
6 · The paper itself

Abstract

Mindfulness-based interventions have been heralded as promising means of alleviating chronic stress. While meta-analyses indicate that mindfulness-based interventions significantly reduce global measures of stress, how mindfulness-based interventions modulate the specific mechanisms underpinning chronic stress as operationalized by the National Institute of Mental Health research domain criteria (RDoC) of sustained threat has not yet been detailed in the literature. To address this knowledge gap, this article aims to (1) review evidence that mindfulness-based interventions ameliorate each of the 10 elements of behavioral dysregulation characterizing sustained threat via an array of mindful counter-regulatory strategies; (2) review evidence that mindfulness-based interventions modify biological domains implicated in sustained threat, such as the hypothalamic-pituitary-adrenal axis, as well as brain circuits involved in attentional function, limbic reactivity, habit behavior, and the default mode network; and (3) integrate these findings into a novel conceptual framework of mindful self-regulation in the face of stress-the Mindfulness-to-Meaning Theory. Taken together, the extant body of scientific evidence suggests that the practice of mindfulness enhances a range biobehavioral factors implicated in adaptive stress coping and induces self-referential plasticity, leading to the ability to find meaning in adversity. These mechanistic findings can inform the treatment development process to optimize the next generation of mindfulness-based interventions for greater therapeutic efficacy.

Indexed as

allostatic loadamygdalaattention networkdefault mode networkhabit systemshypothalamic–pituitary–adrenal axismindfulness-to-meaningreappraisalstresssustained threat

Identifiers

PMID28840198
PMCPMC5565157
OpenAlexW2696684856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.