Evidence map›Paper›PMID 28840050›Full record

ArticleCase reports in pathology2017

Gastric Medullary Carcinoma with Sporadic Mismatch Repair Deficiency and a

Brett M Lowenthal, Theresa W Chan, John A Thorson, Kaitlyn J Kelly, Thomas J Savides, Mark A Valasek

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Gastric Medullary Carcinoma.Radiology. Imaging cancer · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brett M LowenthalDepartment of Pathology, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA.ORCID 0000-0002-5457-1381
Theresa W ChanDepartment of Surgery, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA.
John A ThorsonDepartment of Pathology, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA.
Kaitlyn J KellyDepartment of Surgery, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA.
Thomas J SavidesDepartment of Medicine, Division of Gastroenterology, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA.ORCID 0000-0001-5585-5979
Mark A ValasekDepartment of Pathology, University of California, San Diego, 200 West Arbor Drive, MC 8320, San Diego, CA 92103, USA.ORCID 0000-0003-1721-3451
University of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medullary carcinoma has long been recognized as a subtype of colorectal cancer associated with microsatellite instability and Lynch syndrome. Gastric medullary carcinoma is a very rare neoplasm. We report a 67-year-old male who presented with a solitary gastric mass. Total gastrectomy revealed a well-demarcated, poorly differentiated carcinoma with an organoid growth pattern, pushing borders, and abundant peritumoral lymphocytic response. The prior cytology was cellular with immunohistochemical panel consistent with upper gastrointestinal/pancreaticobiliary origin. Overall, the histopathologic findings were consistent with gastric medullary carcinoma. A mismatch repair panel revealed a mismatch repair protein deficient tumor with loss of MLH1 and PMS2 expression. BRAF V600E immunostain (VE1) and

Identifiers

PMID28840050
PMCPMC5559920
OpenAlexW2745084366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.