Evidence map›Paper›PMID 28839929›Full record

ReviewInterface focus2017

Why an extended evolutionary synthesis is necessary.

Gerd B Müller

Erratum issuedAbstract readReview
In one paragraph

Review in Interface focus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Article
  3. Enzyme Catalytic Parameters and Evolution Across the Dissipation Plane.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Introducing the EpGEpigenomes · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Adaptation and Plasticity ofEvolutionary applications · 2025
    Article
  10. Why did the human brain size evolve? A way forward.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Thomas S. Kuhn: key to a better understanding of the extended evolutionary synthesis.Theory in biosciences = Theorie in den Biowissenschaften · 2024
    Article
  15. Evolution and sustainability: gathering the strands for an Anthropocene synthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Gerd B MüllerDepartment of Theoretical Biology, University of Vienna, Vienna, Austria.ORCID 0000-0001-5011-0193

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the last major theoretical integration in evolutionary biology-the modern synthesis (MS) of the 1940s-the biosciences have made significant advances. The rise of molecular biology and evolutionary developmental biology, the recognition of ecological development, niche construction and multiple inheritance systems, the '-omics' revolution and the science of systems biology, among other developments, have provided a wealth of new knowledge about the factors responsible for evolutionary change. Some of these results are in agreement with the standard theory and others reveal different properties of the evolutionary process. A renewed and extended theoretical synthesis, advocated by several authors in this issue, aims to unite pertinent concepts that emerge from the novel fields with elements of the standard theory. The resulting theoretical framework differs from the latter in its core logic and predictive capacities. Whereas the MS theory and its various amendments concentrate on genetic and adaptive variation in populations, the extended framework emphasizes the role of constructive processes, ecological interactions and systems dynamics in the evolution of organismal complexity as well as its social and cultural conditions. Single-level and unilinear causation is replaced by multilevel and reciprocal causation. Among other consequences, the extended framework overcomes many of the limitations of traditional gene-centric explanation and entails a revised understanding of the role of natural selection in the evolutionary process. All these features stimulate research into new areas of evolutionary biology.

Indexed as

evolutionary biologyevolutionary developmental biologyextended synthesismodern synthesisniche constructionsystems biology

Identifiers

PMID28839929
PMCPMC5566817

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.