ArticleJournal of oral microbiology2017
Salivary cytokine levels in early gingival inflammation.
Article in Journal of oral microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
- The Mechanism and Pathways of Formation and Modification of Salivary Metabolic Profile in Cancer.Current issues in molecular biology · 2026Review
- Dental Amalgam and Oral Biological Responses: A Narrative Review of Current Evidence.Dentistry journal · 2026Review
- The inflammation-pyroptosis axis links local and systemic biomarker profiles to active alveolar bone microstructural deterioration.Frontiers in physiology · 2026Article
- A Comparative Analysis of Feeding Practices and Oral Immunity in Infants.Medicina (Kaunas, Lithuania) · 2025Article
- Natural and induced immune responses in oral cavity and saliva.BMC immunology · 2025Review
- Correlation between concentrations of salivary and gingival crevicular fluid inflammatory cytokines in patients with gingivitis and periodontitis and healthy individuals.Journal of advanced periodontology & implant dentistry · 2025Article
- Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children.Scientific reports · 2025Article
- Comparison of oncostatin M cytokine levels in saliva and serum in periodontitis: a clinicobiochemical study.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2024Article
- Saliva-Based Protein Analysis in Pediatric Dentofacial Inflammation.Pediatric health, medicine and therapeutics · 2024Article
- Exploring the Relationship Between Gingivitis and Hypothyroidism in Children.Galen medical journal · 2024Review
- MAT2A inhibition suppresses inflammation inJournal of oral microbiology · 2024Article
- A physiologically relevant culture platform for long-term studies of in vitro gingival tissue.Acta biomaterialia · 2023Article
- Three-Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Associations between saliva and plasma cytokines in cognitively normal, older adults.Aging clinical and experimental research · 2023Article
- Associations between salivary cytokines and oral health, age, and sex in healthy children.Scientific reports · 2022Article
- Inflammatory phenotype modulation in the respiratory tract and systemic circulation of e-cigarette users: a pilot study.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Evaluation of salivary biomarkers for the diagnosis of periodontitis.BMC oral health · 2021Article
- Salivary and serum markers of angiogenesis in periodontitis in relation to smoking.Clinical oral investigations · 2021Article
- Best practice recommendations for the measurement and interpretation of salivary proinflammatory cytokines in biobehavioral research.Brain, behavior, and immunity · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salivary protein levels have been studied in periodontitis. However, there is lack of information on salivary cytokine levels in early gingival inflammation. The aim of this study was to determine salivary levels of vascular endothelial growth factor (VEGF), interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, IL-1β, and IL-1 receptor antagonist (IL-1Ra) in gingival inflammation. Twenty-eight systemically and orally healthy nonsmokers abstained from oral hygiene protocols for 10 days. After that, self-performed cleaning was resumed for 14 days. Plaque and gingival indexes were measured, and saliva samples were collected at days 1, 4, 7, 10, and 24. Salivary cytokines were detected with Luminex®-xMAP™. Salivary IL-1β, IL-1Ra, and VEGF levels decreased after 10 days' development of experimental gingivitis and reached baseline levels at the end of the 2-week resolution period. Salivary IL-8 levels decreased and remained low during development and resolution of experimental gingivitis. Initial inflammation in gingival tissues is associated with a decrease in inflammatory cytokines in saliva. Further studies are needed to evaluate if inflammatory cytokines bind to their functional receptors within the gingival tissue during early gingivitis, which may limits their spillover to the gingival crevice and ultimately saliva.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.