ArticleThe open virology journal2017
Pathogenic Characterization of European Genotype Porcine Reproductive and Respiratory Syndrome Virus Recently Isolated in Mainland China.
Article in The open virology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Genetic evolutionary and pathogenicity analyses of a novel porcine reproductive and respiratory syndrome virus 1 strain SC202404 that emerged in Southwestern China.BMC veterinary research · 2026Article
- Emergence and Pathogenicity of a Novel PRRSV-1 Strain GD18-2 in Southern China.Animals : an open access journal from MDPI · 2026Article
- Research progress on NSP4 protein of porcine reproductive and respiratory syndrome virus.Veterinary research communications · 2026Review
- Development of a novel duplex crystal digital PCR for the detection of PRRSV-1 and PRRSV-2.Frontiers in cellular and infection microbiology · 2026Article
- Evolution of Porcine Virus Isolation: Guidelines for Practical Laboratory Application.Microorganisms · 2025Review
- Detection and genetic evolution analysis of porcine reproductive and respiratory syndrome virus in Chengdu from January 2021 to December 2022.Journal of veterinary science · 2025Article
- Article
- Genetic variation in NSP4 of type 1 porcine reproductive and respiratory syndrome virus in China.BMC veterinary research · 2025Article
- Article
- Whole-Genomic Characterization of Two Different PRRSV-1 Strains Isolated From a Single Pig.Transboundary and emerging diseases · 2025Article
- Dissecting Genetic Diversity and Evolutionary Trends of Chinese PRRSV-1 Based on Whole-Genome Analysis.Transboundary and emerging diseases · 2024Article
- Characterization and Pathogenicity of the Novel Porcine Reproductive and Respiratory Syndrome Virus 1 Strain SL-01 in China.Transboundary and emerging diseases · 2024Article
- Whole Genome Characterization and Pathogenicity of a SC2020-1-Like PRRSV-1 Strain Emerging in Southwest China.Transboundary and emerging diseases · 2024Article
- Article
- Histopathological Pulmonary Lesions in 1st-Day Newborn Piglets Derived from PRRSV-1 MLV Vaccinated Sows at the Last Stage of Gestation.Life (Basel, Switzerland) · 2023Article
- Recent Progress in Studies of Porcine Reproductive and Respiratory Syndrome Virus 1 in China.Viruses · 2023Review
- Genomic Characterization and Pathogenicity of BJEU06-1-Like PRRSV-1 ZD-1 Isolated in China.Transboundary and emerging diseases · 2023Article
- Metagenomic and Pathogenic Assessments Identify a Pathogenic Porcine Reproductive and Respiratory Syndrome Virus 1 with New Deletions from Adult Slaughter Pig in 2022.Transboundary and emerging diseases · 2023Article
- Emergence of a novel PRRSV-1 strain in mainland China: A recombinant strain derived from the two commercial modified live viruses Amervac and DV.Frontiers in veterinary science · 2022Article
- Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPorcine reproductive and respiratory syndrome virus (PRRSV) is an important pathogen in pig that causes tremendous economic loss in the global swine industry. PRRSV is divided into the European and North American genotypes, with virulence ranging from apathogenic-moderately virulent to highly pathogenic. The emergence of new highly virulent type 1 strains and coexistence of the two genotypes complicate the differential diagnosis, disease prevention, and control of PRRSV. Although the emergence of a novel type 1 PRRSV strain in mainland China was first confirmed in 2011, there is no information available concerning the pathogenesis of this strain.
objectivesWe sought to determine the pathogenesis of a newly emerged Chinese type 1 PRRSV strain HLJB1.
methodsPigs were infected with HLJB1 and characterized using serological and histopathological tests.
resultsHLJB1 infection induced transient chemosis, reddened conjunctiva, skin cyanosis, mild transient pyrexia, dyspnea, and tachypnea between 7 and 13 days post-infection. Gross pneumonic lesions were characterized by multifocal, tan-mottled areas. Lymph nodes and spleen were enlarged. Characteristic microscopic lesions consisted of pulmonary consolidation and alveolar septal thickening with red blood cell infiltration, depletion of splenic lymphocytes, and hyperplasia and activation of macrophage. No pigs infected with HLJB1 died during the experiment.
conclusionOur findings indicate that Chinese type I PRRSV strain HLJB1 caused classic PRRSV-specific lesions. As it caused lower viremia in pigs compared with other classic type 1 isolates, HLJB1 is less virulent than other type I strains.
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