ArticleThe open microbiology journal2017
Sub-Inhibitory Concentrations of Rifampicin Strongly Stimulated Biofilm Production in
Article in The open microbiology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of Sub-Inhibitory Rifampicin, Minocycline, and Dalbavancin on Early Biofilm Formation and Transcriptional Responses inMicroorganisms · 2026Article
- Virulence determinants and multidrug resistance profiles of biofilm-forming Staphylococcus aureus from healthy orthopedic surgical personnel.Antonie van Leeuwenhoek · 2026Article
- Alteration of fimbria-mediated biofilm formation and virulence in the zoonotic pathogenMicrobiology spectrum · 2026Article
- Influence of sub-inhibitory concentrations of antiseptics on biofilm formation in S. epidermidis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Sub-inhibitory concentrations of ceftriaxone induce morphological alterations and PIA-independent biofilm formation in Staphylococcus aureus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Exploring diflunisal as a synergistic agent againstFrontiers in microbiology · 2024Article
- Biofilm formation of two genetically diverseFrontiers in microbiology · 2023Article
- Activity of Exebacase (CF-301) against Biofilms Formed by Staphylococcus epidermidis Strains Isolated from Prosthetic Joint Infections.Antimicrobial agents and chemotherapy · 2022Article
- No Correlation between Biofilm-Forming Capacity and Antibiotic Resistance in EnvironmentalPathogens (Basel, Switzerland) · 2022Article
- Synergy between Indoloquinolines and Ciprofloxacin: An Antibiofilm Strategy againstAntibiotics (Basel, Switzerland) · 2021Article
- Virulence alterations in staphylococcus aureus upon treatment with the sub-inhibitory concentrations of antibiotics.Journal of advanced research · 2021Review
- Correlation Between Biofilm-Formation and the Antibiotic Resistant Phenotype inInfection and drug resistance · 2021Article
- Antibiotic Tolerance ofAntibiotics (Basel, Switzerland) · 2020Review
- Tedizolid-Rifampicin Combination Prevents Rifampicin-Resistance onFrontiers in microbiology · 2020Article
- Phenotypic Characterization ofPathogens (Basel, Switzerland) · 2019Article
- Monohexosylceramides fromMolecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectives
methodsMicrotiter Plate assay and Congo Red Agar Test were used to analyze the biofilm production. The biofilm composition was evaluated by the detachment assay with sodium metaperiodate and proteinase K.
resultsRifampicin sub-MICs induced very high biofilm formation in seven isolates that were non-producers in Tryptic Soy Broth. In one producer isolate, the biofilm formation level was not affected by sub-MICs of this drug. Sub-MICs of minocycline did not induce biofilm production in all isolates tested and in two producer isolates, instead, MIC/2 and MIC/4 inhibited biofilm production. The results of the drugs in combination were similar to those with rifampicin alone. The biofilm matrix was identified as polysaccharide, except for one producer isolate, classified as proteinaceous. Polysaccharide biofilm producer isolates, when grown on Congo Red Agar without sucrose, but with sub-MICs of rifampicin, showed results in agreement with those obtained in Microtiter Plate Test.
conclusionThe high biofilm production induced by sub-MICs of rifampicin has potential clinical relevance, because this is one of the drugs commonly used in the impregnation of catheters. In addition, it is used adjunctively to treat certain
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Registered trials
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