Evidence map›Paper›PMID 28839438›Full record

ArticleWorld journal of gastroenterology2017

Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma.

Masayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Takeshi Goya, Kenta Motomura, Motoyuki Kohjima, Masaki Kato, Akihide Masumoto, Kazuhiro Kotoh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Masayuki MiyazakiMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Masayoshi YadaMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Kosuke TanakaMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Takeshi SenjyuMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Takeshi GoyaMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Kenta MotomuraMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Motoyuki KohjimaMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Masaki KatoMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Akihide MasumotoMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Kazuhiro KotohMasayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan.
Harasanshin Hospital · JPAso Iizuka Hospital · JPKyushu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the factors influenced the efficacy of tolvaptan (TLV) in liver cirrhosis.

methodsWe retrospectively enrolled 61 consecutive patients with refractory hepatic ascites. All of them had been treated with furosemide and spironolactone before admission, and treated with TLV for 7 d in our hospital. The effect of TLV was defined by the rate of body weight loss, and the factors that influenced TLV efficacy were analyzed using multiple regression.

resultsCoexistent hepatocellular carcinoma (HCC) was the only significant predictive variable that attenuated the efficacy of TLV. In stratified analysis, high doses of furosemide decreased the efficacy of TLV in patients with HCC, and increased efficacy in those without HCC. In the latter, a high Child-Pugh-Turcotte score had a positive influence and a high concentration of lactate dehydrogenase had a negative influence on the effectiveness of TLV.

conclusionDevelopment of ascites may differ between patients with liver failure and those with HCC progression. A sufficient preceding dose of furosemide decreases diuretic effect of TLV.

Indexed as

AgedAged, 80 and overAntidiuretic Hormone Receptor AntagonistsAscitesBenzazepinesBody WeightCarcinoma, HepatocellularDisease ProgressionDiureticsDose-Response Relationship, DrugDrug InteractionsDrug ResistanceDrug Therapy, CombinationFemaleFurosemideHumansAntidiuretic Hormone Receptor AntagonistsBenzazepinesDiureticsFurosemideSpironolactoneTolvaptanAscitesCirrhosisFurosemideHepatocellular carcinomaTolvaptan

Identifiers

PMID28839438
PMCPMC5550787
OpenAlexW2744314691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.