Evidence map›Paper›PMID 28839431›Full record

ArticleWorld journal of gastroenterology2017

Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT

Hyun Jung Kim, Guem San Lee, Hyungwoo Kim, Byung Joo Kim

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hyun Jung KimHyun Jung Kim, Byung Joo Kim, Division of Longevity and Biofunctional Medicine, Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University, Yangsan 50612, South Korea.
Guem San LeeHyun Jung Kim, Byung Joo Kim, Division of Longevity and Biofunctional Medicine, Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University, Yangsan 50612, South Korea.
Hyungwoo KimHyun Jung Kim, Byung Joo Kim, Division of Longevity and Biofunctional Medicine, Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University, Yangsan 50612, South Korea.
Byung Joo KimHyun Jung Kim, Byung Joo Kim, Division of Longevity and Biofunctional Medicine, Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University, Yangsan 50612, South Korea.
Wonkwang University · KRPusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effects of a water extract of Hwangryunhaedok-tang (HHTE) on the pacemaker potentials of mouse interstitial cells of Cajal (ICCs).

methodsWe dissociated ICCs from small intestines and cultured. ICCs were immunologically identified using an anti-c-kit antibody. We used the whole-cell patch-clamp configuration to record the pacemaker potentials generated by cultured ICCs under the current clamp mode (

resultsHHTE dose-dependently depolarized ICC pacemaker potentials. Pretreatment with a 5-HT

conclusionThese results suggest that HHTE dose-dependently depolarizes ICC pacemaker potentials through 5-HT

Indexed as

AnimalsBiological ClocksBridged Bicyclo Compounds, HeterocyclicCalciumCells, CulturedDrugs, Chinese HerbalEnzyme InhibitorsGastrointestinal MotilityGTP-Binding ProteinsInterstitial Cells of CajalIntestine, SmallMembrane PotentialsMiceMice, Inbred ICROxazinesPatch-Clamp TechniquesazasetronBridged Bicyclo Compounds, HeterocyclicCalciumDrugs, Chinese HerbalEnzyme InhibitorsGTP-Binding Proteinshwangryunhaedok-tangOxazinesPhenolsPiperidinesPlant ExtractsPropaneProtein Kinase CReceptors, Serotoninrho-Associated KinasesRS 39604SB 269970Serotonin 5-HT3 Receptor AntagonistsSerotonin 5-HT4 Receptor Antagonistsserotonin 7 receptorSulfonamidesThapsigarginGastrointestinal tractHwangryunhaedok-tangInterstitial cells of CajalMotilityPacemaker potentials

Identifiers

PMID28839431
PMCPMC5550780
OpenAlexW2742703711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.