ArticleScientific reports2017
Cerium oxide nanoparticles inhibit differentiation of neural stem cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
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- Nanoceria as Next-Generation Immunotherapeutics: Applications in Chronic Inflammation, Cancer, and Tissue Repair.Journal of nanotheranostics · 2025Article
- Biocompatibility testing and antioxidant properties of cerium dioxide nanoparticles in human nervous system cells.Archives of toxicology · 2025Article
- Membrane-Camouflaged Biomimetic Nanoparticles for Effective Ischemic Stroke Therapeutics? A Comprehensive Review of the Literature.International journal of nanomedicine · 2025Review
- Dopaminergic- and Serotonergic-Dependent Behaviors Are Altered by Lanthanide Series Metals inToxics · 2024Article
- Ceria nanoparticles: biomedical applications and toxicity.Journal of Zhejiang University. Science. B · 2024Review
- Molecular Mechanisms in Metal Oxide Nanoparticle-Tryptophan Interactions.Inorganic chemistry · 2024Article
- Biosynthesized Silver Nanoparticles fromCurrent pharmaceutical biotechnology · 2024Article
- Cerium Oxide Nanoparticles Protect Cortical Astrocytes from Oxygen-Glucose Deprivation through Activation of the CaInternational journal of molecular sciences · 2023Article
- Continuous Production of Highly Tuned Silk/Calcium-Based Composites: Exploring New Pathways for Skin Regeneration.Molecules (Basel, Switzerland) · 2022Article
- Graphene nanoplatelets/CeOApplied nanoscience · 2022Article
- Nanoantioxidants: Pioneer Types, Advantages, Limitations, and Future Insights.Molecules (Basel, Switzerland) · 2021Review
- Internalized Nanoceria Modify the Radiation-Sensitivity Profile of MDA MB231 Breast Carcinoma Cells.Biology · 2021Article
- Influence of CeInternational journal of molecular sciences · 2021Article
- Nanostructured Ceria: Biomolecular Templates and (Bio)applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Nanotechnology Facilitated Cultured Neuronal Network and Its Applications.International journal of molecular sciences · 2021Review
- Profiling of Sub-Lethal in Vitro Effects of Multi-Walled Carbon Nanotubes Reveals Changes in Chemokines and Chemokine Receptors.Nanomaterials (Basel, Switzerland) · 2021Article
- Ni and TiOEnvironmental science and pollution research international · 2021Article
- The Role of Nanomaterials in Stroke Treatment: Targeting Oxidative Stress.Oxidative medicine and cellular longevity · 2021Review
- Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism.Molecular medicine reports · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerium oxide nanoparticles (nanoceria) display antioxidant properties and have shown cytoprotective effects both in vitro and in vivo. Here, we explored the effects of nanoceria on neural progenitor cells using the C17.2 murine cell line as a model. First, we assessed the effects of nanoceria versus samarium (Sm) doped nanoceria on cell viability in the presence of the prooxidant, DMNQ. Both particles were taken up by cells and nanoceria, but not Sm-doped nanoceria, elicited a temporary cytoprotective effect upon exposure to DMNQ. Next, we employed RNA sequencing to explore the transcriptional responses induced by nanoceria or Sm-doped nanoceria during neuronal differentiation. Detailed computational analyses showed that nanoceria altered pathways and networks relevant for neuronal development, leading us to hypothesize that nanoceria inhibits neuronal differentiation, and that nanoceria and Sm-doped nanoceria both interfere with cytoskeletal organization. We confirmed that nanoceria reduced neuron specific β3-tubulin expression, a marker of neuronal differentiation, and GFAP, a neuroglial marker. Furthermore, using super-resolution microscopy approaches, we could show that both particles interfered with cytoskeletal organization and altered the structure of neural growth cones. Taken together, these results reveal that nanoceria may impact on neuronal differentiation, suggesting that nanoceria could pose a developmental neurotoxicity hazard.
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