ArticleScientific reports2017
Mapping the 'Two-component system' network in rice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Exploring the Genetic Landscape of Histidine Phosphotransfer Proteins in the Oryza Genus.Molecular biotechnology · 2026Article
- A coordinated network of MYB regulators orchestrates anthocyanin biosynthesis in banana.Horticulture research · 2026Article
- An Unusual Component of the Multistep Phosphorelay from Tea Plant (International journal of molecular sciences · 2026Article
- Type-A and -C response regulator genes positively impact rice plant height and panicle architecture.Plant cell reports · 2025Article
- Non-Canonical Inter-Protein Interactions of Key Proteins Belonging to Cytokinin Signaling Pathways.Plants (Basel, Switzerland) · 2025Review
- Genome-wide identification and functional characterization of the two-component system gene family in petunia reveals roles in hormone signaling and stress response.Frontiers in plant science · 2025Article
- Primary multistep phosphorelay activation comprises both cytokinin and abiotic stress responses: insights from comparative analysis of Brassica type-A response regulators.Journal of experimental botany · 2024Article
- Genome-wide identification and expression analysis of two-component system genes in switchgrass (Panicum virgatum L.).BMC plant biology · 2024Article
- Article
- Dissection of Developmental Programs and Regulatory Modules Directing Endosperm Transfer Cell and Aleurone Identity in the Syncytial Endosperm of Barley.Plants (Basel, Switzerland) · 2023Article
- Genome-wide identification and expression profiling of two-component system (TCS) genes inFrontiers in genetics · 2023Article
- Improvement of Rice Agronomic Traits by Editing Type-B Response Regulators.International journal of molecular sciences · 2022Article
- Genome-wide identification and expression analysis of two-component system genes in sweet potato (Frontiers in plant science · 2022Article
- The Adaptation and Tolerance of Major Cereals and Legumes to Important Abiotic Stresses.International journal of molecular sciences · 2021Review
- Two-component signaling system in plants: interaction network and specificity in response to stress and hormones.Plant cell reports · 2021Review
- Elucidating the Response of Crop Plants towards Individual, Combined and Sequentially Occurring Abiotic Stresses.International journal of molecular sciences · 2021Review
- The Journey from Two-Step to Multi-Step Phosphorelay Signaling Systems.Current genomics · 2021Review
- Differential gene expression reveals mechanisms related to habitat divergence between hybridizing orchids from the Neotropical coastal plains.BMC plant biology · 2020Article
- The Interaction Network and Signaling Specificity of Two-Component System inInternational journal of molecular sciences · 2020Review
- Histidine kinase MHZ1/OsHK1 interacts with ethylene receptors to regulate root growth in rice.Nature communications · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two-component system (TCS) in plants is a histidine to aspartate phosphorelay based signaling system. Rice genome has multifarious TCS signaling machinery comprising of 11 histidine kinases (OsHKs), 5 histidine phosphotransferases (OsHPTs) and 36 response regulators (OsRRs). However, how these TCS members interact with each other and comprehend diverse signaling cascades remains unmapped. Using a highly stringent yeast two-hybrid (Y2H) platform and extensive in planta bimolecular fluorescence complementation (BiFC) assays, distinct arrays of interaction between various TCS proteins have been identified in the present study. Based on these results, an interactome map of TCS proteins has been assembled. This map clearly shows a cross talk in signaling, mediated by different sensory OsHKs. It also highlights OsHPTs as the interaction hubs, which interact with OsRRs, mostly in a redundant fashion. Remarkably, interactions between type-A and type-B OsRRs have also been revealed for the first time. These observations suggest that feedback regulation by type-A OsRRs may also be mediated by interference in signaling at the level of type-B OsRRs, in addition to OsHPTs, as known previously. The interactome map presented here provides a starting point for in-depth molecular investigations for signal(s) transmitted by various TCS modules into diverse biological processes.
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