ArticleScientific reports2017
The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- The Effect of Assisted Reproductive Technologies on Human Sex Ratios.The Australian & New Zealand journal of obstetrics & gynaecology · 2025Article
- Parental mixed-gender preferences revealed by IVF twin births.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Insemination methods for embryos transferred in frozen-thawed embryo transfer cycles do not impact reproductive outcomes in couples with non-male factor infertility.Scientific reports · 2025Article
- Sex ratio shift after frozen single blastocyst transfer in relation to blastocyst morphology parameters.Scientific reports · 2024Article
- Factors influencing sex ratio at birth in Krosno, Poland.Scientific reports · 2024Article
- Assisted reproductive technology induces different secondary sex ratio: parental and embryonic impacts.Reproductive health · 2023Article
- Sleep quality is associated with the weight of newborns after in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI).Sleep & breathing = Schlaf & Atmung · 2022Article
- Embryo quality, ploidy, and transfer outcomes in male versus female blastocysts.Journal of assisted reproduction and genetics · 2021Article
- Morphology-based selection from available euploid blastocysts induces male-skewed sex proportion in the offspring.Journal of assisted reproduction and genetics · 2021Article
- Twinning during the pandemic: Evidence of selectionEvolution, medicine, and public health · 2021Article
- Associated factors of secondary sex ratio of offspring in assisted reproductive technology: a cross-sectional study in Jilin Province, China.BMC pregnancy and childbirth · 2020Article
- Developmental Plasticity in Response to Embryo Cryopreservation: The Importance of the Vitrification Device in Rabbits.Animals : an open access journal from MDPI · 2020Article
- Secondary sex ratio in assisted reproduction: an analysis of 1 376 454 treatment cycles performed in the UK.Human reproduction open · 2019Article
- Neonate female to male ratio after assisted reproduction following antagonist and agonist protocols.Medicine · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to evaluate the impact of assisted reproductive technology (ART) procedure and individual factors on the sex ratio of singletons and twins at birth after in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI) treatment in China. We conducted a retrospective cohort study including patients undergoing their first cycle of IVF or ICSI with autologous oocytes from 2001 to 2015. A total of 7410 babies were born from 5832 women with 7410 live birth. The secondary sex ratio (SSR) in singletons was significantly higher than twins (53.97% vs. 50.89%, P = 0.009). The largest disparity was observed in 'thawed blastocyst embryos ICSI' subgroup that SSR was 59.84% in singletons and 42.45% in twins (P = 0.013). Blastocyst transfer was positively associated with elevated SSR when compared to cleavage stage embryos in singletons (Odds Ratio [OR] = 1.17, P < 0.001). In addition, paternal age was significantly associated with SSR (OR = 0.75, P = 0.014). While the decrease of SSR was significantly associated with ICSI when compared to IVF (OR = 0.61, P = 0.046) in twins. Blastocyst transfer increases SSR in comparing with cleavage stage embryos in singletons, while the use of ICSI reduces SSR in twins. Our findings offered important complement for better understanding the underlying determinant of SSR in ART offspring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.