Evidence map›Paper›PMID 28839131›Full record

ArticleNature communications2017

Whi7 is an unstable cell-cycle repressor of the Start transcriptional program.

Mercè Gomar-Alba, Ester Méndez, Inma Quilis, M Carmen Bañó, J Carlos Igual

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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  11. Pho85 and PI(4,5)PBiochimica et biophysica acta. Molecular and cell biology of lipids · 2020
    Article
  12. Review
  13. Article
  14. Cell cycle regulated expression of theCell cycle (Georgetown, Tex.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mercè Gomar-AlbaDepartament de Bioquímica i Biologia Molecular and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, 46100, Valencia, Spain.
Ester MéndezDepartament de Bioquímica i Biologia Molecular and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, 46100, Valencia, Spain.
Inma QuilisDepartament de Bioquímica i Biologia Molecular and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, 46100, Valencia, Spain.
M Carmen BañóDepartament de Bioquímica i Biologia Molecular and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, 46100, Valencia, Spain.
J Carlos IgualDepartament de Bioquímica i Biologia Molecular and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, 46100, Valencia, Spain. jcigual@uv.es.
Universitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Start is the main decision point in eukaryotic cell cycle in which cells commit to a new round of cell division. It involves the irreversible activation of a transcriptional program by G1 CDK-cyclin complexes through the inactivation of Start transcriptional repressors, Whi5 in yeast or Rb in mammals. Here we provide novel keys of how Whi7, a protein related at sequence level to Whi5, represses Start. Whi7 is an unstable protein, degraded by the SCF

Indexed as

Cell Cycle CheckpointsCyclinsGene Expression Regulation, FungalRepressor ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription, GeneticCLN3 protein, S cerevisiaeCyclinsRepressor ProteinsSaccharomyces cerevisiae ProteinsWhi5 protein, S cerevisiaeWhi7 protein, S cerevisiae

Identifiers

PMID28839131
PMCPMC5571219
OpenAlexW2746439291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.