ArticleAnnals of transplantation2017
C1q Test for Identification of Sensitized Liver Recipients at Risk of Early Acute Antibody-Mediated Rejection.
Article in Annals of transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Immunopathogenesis of antibody-mediated rejection in liver transplantation.Frontiers in immunology · 2026Review
- HLA, Non-HLA Antibodies, and Eplet Mismatches in Pediatric Liver Transplantation: Observations From a Small, Single-Center Cohort.Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2019Article
- FCGR3A and FCGR2A Genotypes Differentially Impact Allograft Rejection and Patients' Survival After Lung Transplant.Frontiers in immunology · 2019Article
- Tailoring desensitization in intestinal transplants: C1q guided protocol for highly sensitized recipients.Intestinal Failure (New York, N.Y.)Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND The majority of liver recipients transplanted with positive crossmatch have a post-transplant course free of acute antibody-mediated rejection (AMR). However, 10% of sensitized recipients develop early severe AMR. There is no clear strategy that would allow for predicting the postoperative course in sensitized liver recipients. One of the possible factors contributing to the dichotomous course in sensitized recipients may be the complement-binding characteristics of the donor-specific antibodies (DSA). MATERIAL AND METHODS We tested sera of sensitized recipients with DSA at the time of transplant, diagnosed with severe AMR or 'AMR-free' for C1q reactivity and strength of mean fluorescence intensity (MFI) in single-antigen beads (SAB) assay. RESULTS Both groups tested positive for DSA C1q binding and DSA-SAB. Recipients with early AMR had significantly stronger DSA MFI in the C1q assay (P<.0001). AMR was observed in patients with very high DSA C1q MFI (22681±8841 vs. the no-AMR group 7954±2061). In SAB assay, DSA MFI strength differences were equivocal (P=0.31). CONCLUSIONS The C1q test is a supportive adjunct in identifying patients at risk of postoperative acute AMR and selects an AMR-free course with 100% negative predictive value despite the presence of DSA.
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