Evidence map›Paper›PMID 28838957›Full record

ArticleThe Journal of cell biology2017

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.

Jiayi Yao, Pierre J Guihard, Xiuju Wu, Ana M Blazquez-Medela, Melissa J Spencer, Medet Jumabay, Peter Tontonoz, Alan M Fogelman, Kristina I Boström, Yucheng Yao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jiayi YaoDivision of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Pierre J GuihardDivision of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0001-5824-0160
Xiuju WuDivision of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Ana M Blazquez-MedelaDivision of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Melissa J SpencerDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0001-7104-544X
Medet JumabayDivision of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0002-0111-8612
Peter TontonozDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Alan M FogelmanDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Kristina I BoströmDivision of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA kbostrom@mednet.ucla.edu.
Yucheng YaoDivision of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA yyao@mednet.ucla.edu.ORCID 0000-0003-0483-9180
University of California, Los Angeles · USHoward Hughes Medical Institute · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
Molecular Mechanisms of MGP; Role in AVMsR01HL081397 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2006 to 2025
$7.7M
UCLA Muscular Dystrophy Core CenterP30AR057230 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SPENCER, MELISSA JAN · 2009 to 2018
$6.2M
BMP and Notch Crosstalk in Cerebral Arteriovenous MalformationsR01NS079353 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2012 to 2026
$5.3M
Role of The Endothelium In Vascular CalcificationR01HL112839 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2013 to 2016
$1.5M
NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R01 HL081397NHLBI NIH HHS R01 HL112839NIAMS NIH HHS P30 AR057230NINDS NIH HHS R01 NS079353
6 · The paper itself

Abstract

The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic differentiation in the pulmonary epithelium. We demonstrate uncontrolled induction of the hepatic growth factor (HGF) caused by dysregulated cross talk between pulmonary endothelium and epithelium in

Indexed as

Cell CommunicationCell DifferentiationAnimalsEndothelium, VascularEpithelial CellsHepatocyte Growth FactorHepatocyte Nuclear Factor 3-betaHepatocyte Nuclear Factor 4MiceMice, KnockoutProteinsRespiratory MucosaFoxa2 protein, mousegranuloma protein, mouseHepatocyte Growth FactorHepatocyte Nuclear Factor 3-betaHepatocyte Nuclear Factor 4HGF protein, mouseHnf4a protein, mouseProteins

Identifiers

PMID28838957
PMCPMC5626536
OpenAlexW2750522049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.