Evidence map›Paper›PMID 28838946›Full record

ArticleGenes & development2017

Histone locus regulation by the

Leila E Rieder, Kaitlin P Koreski, Kara A Boltz, Guray Kuzu, Jennifer A Urban, Sarah K Bowman, Anna Zeidman, William T Jordan, Michael Y Tolstorukov, William F Marzluff and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Leila E RiederDepartment of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.
Kaitlin P KoreskiCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Kara A BoltzLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Guray KuzuDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Jennifer A UrbanDepartment of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.
Sarah K BowmanDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Anna ZeidmanDepartment of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.
William T JordanDepartment of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.
Michael Y TolstorukovDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
William F MarzluffCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Robert J DuronioCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Erica N LarschanDepartment of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.
Brown University · USMassachusetts General Hospital · USUniversity of North Carolina at Chapel Hill · USUNC Lineberger Comprehensive Cancer Center

Funding

Integrated Training in Cancer Model SystemsT32CA009156 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 1985 to 2020
$19.7M
HISTONE MRNA REGULATION IN DEVELOPMENTR01GM058921 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J, MARZLUFF, WILLIAM F. · 1999 to 2025
$11.6M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Establishing coordinate gene regulation during Drosophila dosage compensationR01GM098461 · NIGMS · BROWN UNIVERSITY · PI LARSCHAN, ERICA NICOLE · 2011 to 2016
$2.1M
The role of CLAMP, a novel zinc-finger protein, in Drosophila dosage compensationF32GM109663 · NIGMS · BROWN UNIVERSITY · PI RIEDER, LEILA ELIZABETH · 2014 to 2017
$167k
NCI NIH HHS T32 CA009156NIGMS NIH HHS F32 GM109663NIGMS NIH HHS R01 GM058921NIGMS NIH HHS R01 GM098461NIGMS NIH HHS T32 GM007092
6 · The paper itself

Abstract

The conserved histone locus body (HLB) assembles prior to zygotic gene activation early during development and concentrates factors into a nuclear domain of coordinated histone gene regulation. Although HLBs form specifically at replication-dependent histone loci, the

Indexed as

Gene Expression Regulation, DevelopmentalGenetic LociAnimalsBase SequenceChromatinConserved SequenceDNADNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsHistonesPromoter Regions, GeneticRepetitive Sequences, Nucleic AcidTranscription FactorsChromatinCLAMP protein, DrosophilaDNADNA-Binding ProteinsDrosophila ProteinsHistonesTranscription FactorsTrl protein, DrosophilaCLAMPdosage compensationGAGA factorGA repeatshistone locus bodynuclear bodies

Identifiers

PMID28838946
PMCPMC5588930
OpenAlexW2748024773

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.