Evidence map›Paper›PMID 28838935›Full record

ArticleThe EMBO journal2017

Noise in a phosphorelay drives stochastic entry into sporulation in

Jonathan R Russell, Matthew T Cabeen, Paul A Wiggins, Johan Paulsson, Richard Losick

Abstract read
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Contributions of transcriptional noise to leukaemia evolution: KAT2A as a case-study.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. The motility-matrix production switch inJournal of bacteriology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Valuing what happens: a biogenic approach to valence and (potentially) affect.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Artificial Sporulation Induction (ASI) byInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonathan R RussellDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Matthew T CabeenDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Paul A WigginsDepartments of Physics, Bioengineering and Microbiology, University of Washington, Seattle, WA, USA.
Johan PaulssonDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Richard LosickDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA losick@mcb.harvard.edu.ORCID 0000-0002-5130-6582

Funding

Role of RNA Polymerase in Bacterial DifferentionR01GM018568 · NIGMS · HARVARD UNIVERSITY · PI LOSICK, RICHARD MARC · 1985 to 2018
$11.5M
Limits and Trade-offs of Feedback ControlR01GM081563 · NIGMS · HARVARD MEDICAL SCHOOL · PI Johan Paulsson · 2008 to 2026
$4.9M
ROLE OF RNA POLYMERASE IN BACTERIAL DIFFERENTIATIONR37GM018568 · NIGMS · HARVARD UNIVERSITY · PI LOSICK, RICHARD MARC · 1990 to 1999
–
NIGMS NIH HHS R01 GM018568NIGMS NIH HHS R01 GM081563NIGMS NIH HHS R37 GM018568
6 · The paper itself

Abstract

Entry into sporulation in

Indexed as

Bacillus subtilisBacterial ProteinsGene Expression Regulation, BacterialHistidine KinaseMetabolic Networks and PathwaysMicrofluidic Analytical TechniquesPhosphatesPhosphorylationProtein KinasesSpores, BacterialTranscription FactorsTranscription, GeneticBacterial ProteinsHistidine KinasePhosphatesProtein KinasesSpo0A protein, Bacillus subtilisspore-specific proteins, BacillusTranscription Factorscell fateconstant probabilityphosphorelaysporulation

Identifiers

PMID28838935
PMCPMC5623841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.