ArticleAmerican journal of human genetics1987
Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.
Article in American journal of human genetics, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 96 citations in OpenAlex.
- Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome-wide association on chromosome 1p22.Birth defects research. Part A, Clinical and molecular teratology · 2012Article
- The plasmin-antiplasmin system: structural and functional aspects.Cellular and molecular life sciences : CMLS · 2011Review
- Criteria for specific measurement of plasminogen (enzymatic; procedure) in human plasma.EJIFCC · 2000Review
- Lafora progressive myoclonus epilepsy: narrowing the chromosome 6q24 locus by recombinations and homozygosities.American journal of human genetics · 1997Article
- Fucosidosis: genetic and biochemical analysis of eight cases.Journal of medical genetics · 1997Article
- Lipoprotein(a): new insights into an atherogenic lipoprotein.The Clinical investigator · 1994Review
- Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mapping.American journal of human genetics · 1993Article
- 5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- The plasminogen-plasmin system in malignancy.Cancer metastasis reviews · 1992Review
- alpha-L-fucosidase in human fibroblasts. I. The enzyme activity polymorphism.Biochemical genetics · 1992Article
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis.The Journal of clinical investigation · 1991Article
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- Plasma Ip(a) concentration is inversely correlated with the ratio of Kringle IV/Kringle V encoding domains in the apo(a) gene.The Journal of clinical investigation · 1989Article
- A TaqI RFLP of the human plasminogen gene.Nucleic acids research · 1989Article
- Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.Journal of medical genetics · 1989Article
- Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Heterogeneity of mRNA expression in Italian fucosidosis patients.Human genetics · 1989Article
- The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6.Human genetics · 1989Article
- Restriction analysis of the structural alpha-L-fucosidase gene and its linkage to fucosidosis.American journal of human genetics · 1988Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linkage disequilibrium was observed between newly identified DNA polymorphisms and a previously described protein polymorphism for plasminogen. This finding implies that the two types of polymorphisms describe variation at the same locus. The plasminogen gene was mapped to chromosomal bands 6q26-q27 using somatic-cell hybrids and in situ hybridization. Linkage disequilibrium between protein and DNA polymorphisms has utility in substituting for protein typing in instances where only DNA samples are available, such as from deceased individuals or extinct species. The technique may be useful when cross-hybridizing sequences make the interpretation of Southern blot patterns difficult and may obviate the need for extensive DNA sequencing. In some cases, disequilibrium may provide information useful for determining the appropriate direction for chromosome walks from a marker locus to a target locus.
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Identifiers
2883890PMC1684087W307912763What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.