Evidence map›Paper›PMID 28838855›Full record

ReviewTrends in immunology2017

Exosomes, DAMPs and miRNA: Features of Stress Physiology and Immune Homeostasis.

Monika Fleshner, Camille R Crane

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 3 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 3 syntheses or guidelines pooled it, 210 citations in OpenAlex.

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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Monika FleshnerDepartment of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA; The Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA. Electronic address: fleshner@colorado.edu.
Camille R CraneDepartment of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA.
University of Colorado Boulder · US

Funding

Stress, Heat-Shock Proteins, and Innate ImmunityR01AI057797 · NIAID · UNIVERSITY OF COLORADO AT BOULDER · PI FLESHNER, MONIKA · 2004 to 2008
$1.7M
NIAID NIH HHS R01 AI057797
6 · The paper itself

Abstract

Psychological/physical stressors and local tissue damage increase inflammatory proteins in tissues and blood in humans and animals, in the absence of pathogenic disease. Stress-evoked cytokine/chemokine responses, or sterile inflammation, can facilitate host survival and/or negatively affect health, depending on context. Recent evidence supports the hypothesis that systemic stress-evoked sterile inflammation is initiated by the sympathetic nervous system, resulting in the elevation of exosome-associated immunostimulatory endogenous danger/damage associated molecular patterns (DAMPs) and a reduction in immunoinhibitory miRNA, which are carried in the circulation to tissues throughout the body. We propose that sterile inflammation should be considered an elemental feature of the stress response and that circulating exosomes transporting immunomodulatory signals, may play a role fundamental role in immune homeostasis.

Indexed as

Immune SystemStress, PhysiologicalAlarminsAnimalsExosomesHomeostasisHumansImmunomodulationMicroRNAsStress, PsychologicalAlarminsMicroRNAsdanger associated molecular patternsmiRNAsterile inflammation

Identifiers

PMID28838855
PMCPMC5624844
OpenAlexW2749004660

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.