ArticlePharmacological research2017
Characterization of structurally novel G protein biased CB
Open access · greenAbstract read
In one paragraph
Article in Pharmacological research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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0cells of the map it votes in
24citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Leveraging machine learning for selective cannabinoid ligand discovery: methods, challenges, and opportunities.Expert opinion on drug discovery · 2026Review
- Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well-documented intoxication cases and basic pharmacological data.Addiction (Abingdon, England) · 2026Article
- Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery.Acta pharmacologica Sinica · 2025Review
- Article
- Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hexahydrocannabinol (HHC) and ΔScientific reports · 2024Article
- Cannabinoid Tolerance in S426A/S430A xThe Journal of pharmacology and experimental therapeutics · 2023Article
- Allosteric crosstalk in modular proteins: Function fine-tuning and drug design.Computational and structural biotechnology journal · 2023Review
- Recent Advances in Endocannabinoid System Targeting for Improved Specificity: Strategic Approaches to Targeted Drug Delivery.International journal of molecular sciences · 2022Review
- Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- The endocannabinoid system - current implications for drug development.Journal of internal medicine · 2021Review
- Therapeutic potential and safety considerations for the clinical use of synthetic cannabinoids.Pharmacology, biochemistry, and behavior · 2020Review
- Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands.ACS chemical neuroscience · 2020Article
- Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling.International journal of molecular sciences · 2020Review
- A Guide to Targeting the Endocannabinoid System in Drug Design.International journal of molecular sciences · 2020Review
- Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds.ACS pharmacology & translational science · 2020Article
- In vitro determination of the efficacy of illicit synthetic cannabinoids at CBBritish journal of pharmacology · 2019Article
- Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein-Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with ΔThe Journal of pharmacology and experimental therapeutics · 2019Article
- Structural Insights into CB1 Receptor Biased Signaling.International journal of molecular sciences · 2019Review
- Cannabinoid Signaling in the Skin: Therapeutic Potential of the "C(ut)annabinoid" System.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Benjamin M FordDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: bmford@uams.edu.
Lirit N FranksDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: lnranks@uams.edu.
Sherrica TaiDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: sytai@med.umich.edu.
William E FantegrossiDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: wefantegrossi@uams.edu.
Edward L StahlDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: estahl@scripps.edu.
Michael D BerquistDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: mdberquistii@uams.edu.
Christian V CabanlongDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: cvcabanlong@uams.edu.
Catheryn D WilsonDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: cdwilson2@uams.edu.
Narsimha R PenthalaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: nrpenthala@uams.edu.
Peter A CrooksDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: pacrooks@uams.edu.
Paul L PratherDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: pacrooks@uams.edu.
University of Arkansas for Medical Sciences · USScripps Research Institute · US
Funding
The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI BOERMA, MARJAN · 2015 to 2024
$21.1MTelemedicine CoreP30GM110702 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI GARCIA-RILL, EDGAR E. · 2014 to 2018
$6.1MTranslational Training in AddictionT32DA022981 · NIDA · UNIV OF ARKANSAS FOR MED SCIS · PI Melissa Jean Zielinski · 2009 to 2026
$6.1MSynthetic Cannabinoid Toxicity: Role of BiotransformationR01DA039143 · NIDA · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2016 to 2020
$2.9MNIDA NIH HHS R01 DA039143NIGMS NIH HHS P20 GM109005NIGMS NIH HHS P30 GM110702
Abstract
The human cannabinoid subtype 1 receptor (hCB
Indexed as
Animalsbeta-Arrestin 2Cannabinoid Receptor AgonistsCHO CellsCricetulusCyclohexanolsGTP-Binding ProteinsIndolesMaleMiceNaphthalenesQuinuclidinesReceptor, Cannabinoid, CB11-pentyl-3-(1-naphthoyl)indole3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolbeta-Arrestin 2Cannabinoid Receptor AgonistsCyclohexanolsGTP-Binding ProteinsIndolesNaphthalenesQuinuclidinesReceptor, Cannabinoid, CB1Biased agonistG protein-dependent signalingG protein-independent signalingHuman cannabinoid type-1 receptorIndole quinuclidineSeven transmembrane receptorsβ-Arrestin 2 recruitment
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.