ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2017
Life years lost attributable to late effects after radiotherapy for early stage Hodgkin lymphoma: The impact of proton therapy and/or deep inspiration breath hold.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Role of radiotherapy to bulky sites of advanced Hodgkin lymphoma treated with ABVD: final results of FIL HD0801 trial.Blood advances · 2021Trial
- Improving deep-learning IMRT plan quality for lymphoma using deliverability-aware training.Journal of applied clinical medical physics · 2026Article
- Clinical implementation of intensity modulated proton therapy in breath-hold for mediastinal lymphoma patients using surface monitoring and nasal high-flow therapy.Physics and imaging in radiation oncology · 2026Article
- Improved organs-of-interest dose reduction potential with intensity modulated proton therapy and breath-hold in mediastinal lymphoma.Physics and imaging in radiation oncology · 2026Article
- Comparing Organs at Risk Sparing Between Intensity-Modulated Radiotherapy and Pencil-Beam Scanning Plans Based on Disease Location for Hodgkin and Non-Hodgkin Lymphoma.International journal of particle therapy · 2026Article
- Improved therapies, incomplete data: late toxicity after modern classical Hodgkin Lymphoma radiotherapy.Acta oncologica (Stockholm, Sweden) · 2025Article
- Application of the Deep Inspiration Breath-Hold Technique in Proton Therapy for Mediastinal Lymphomas: Initial Experience.Cancers · 2025Article
- Individualised Estimation of Quality-adjusted Survival Benefit and Cost-effectiveness of Proton Beam Therapy in Intermediate-stage Hodgkin Lymphoma.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2023Article
- Proton linear energy transfer and variable relative biological effectiveness for adolescent patients with Hodgkin lymphoma.BJR open · 2023Article
- Proton Therapy in Supradiaphragmatic Lymphoma: Predicting Treatment-Related Mortality to Help Optimize Patient Selection.International journal of radiation oncology, biology, physics · 2022Article
- Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma.International journal of particle therapy · 2022Article
- The optimal use of PET/CT in the management of lymphoma patients.The British journal of radiology · 2021Review
- Harnessing benefit of highly conformal RT techniques for lymphoma patients.The British journal of radiology · 2021Review
- The risk of late effects following pediatric and adult radiotherapy regimens in Hodgkin lymphoma.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Article
- Current Situation of Proton Therapy for Hodgkin Lymphoma: From Expectations to Evidence.Cancers · 2021Review
- Development and Implementation of Proton Therapy for Hodgkin Lymphoma: Challenges and Perspectives.Cancers · 2021Review
- Pencil beam scanning proton therapy of Hodgkin's lymphoma in deep inspiration breath-hold: A case series report.Technical innovations & patient support in radiation oncology · 2020Article
- Intensity modulated proton therapy compared to volumetric modulated arc therapy in the irradiation of young female patients with hodgkin's lymphoma. Assessment of risk of toxicity and secondary cancer induction.Radiation oncology (London, England) · 2020Article
- Secondary Malignancy Risk Following Proton vs. X-ray Treatment of Mediastinal Malignant Lymphoma: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk.Frontiers in oncology · 2020Article
- Comparative photon and proton dosimetry for patients with mediastinal lymphoma in the era of Monte Carlo treatment planning and variable relative biological effectiveness.Radiation oncology (London, England) · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
background and purposeDue to the long life expectancy after treatment, the risk of late effects after radiotherapy (RT) is of particular importance for patients with Hodgkin lymphoma (HL). Both deep inspiration breath hold (DIBH) and proton therapy have been shown to reduce the dose to normal tissues for mediastinal HL, but the impact of these techniques in combination is unknown. The purpose of this study was to compare the life years lost (LYL) attributable to late effects after RT for mediastinal HL using intensity modulated radiation therapy (IMRT) in free breathing (FB) and DIBH, and proton therapy in FB and DIBH. MATERIALS AND
methodsPlans for each technique were created for 22 patients with HL. Doses were extracted and the risk of late effects and LYL were estimated.
resultsWe found that the use of DIBH, proton therapy, and the combination significantly reduced the LYL compared to IMRT in FB. The lowest LYL was found for proton therapy in DIBH. However, when IMRT in DIBH was compared to proton therapy in FB, no significant difference was found.
conclusionsPatient-specific plan comparisons should be used to select the optimal technique when comparing IMRT in DIBH and proton therapy in FB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.