Evidence map›Paper›PMID 28838487›Full record

ArticleThe Annals of thoracic surgery2017

Cardioscopically Guided Beating Heart Surgery: Paravalvular Leak Repair.

Benoit Rosa, Zurab Machaidze, Margherita Mencattelli, Sunil Manjila, Borami Shin, Karl Price, Michael A Borger, Vinod Thourani, Pedro Del Nido, David W Brown and 3 more

Abstract read
In one paragraph

Article in The Annals of thoracic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Benoit RosaDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
Zurab MachaidzeDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
Margherita MencattelliDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
Sunil ManjilaDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
Borami ShinDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
Karl PriceDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
Michael A BorgerNew York Presbyterian-Columbia University Medical Center, New York, New York.
Vinod ThouraniEmory University, Atlanta, Georgia.
Pedro Del NidoDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
David W BrownDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
Christopher W BairdDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
John E MayerDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
Pierre E DupontDepartment of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts. Electronic address: pierre.dupont@childrens.harvard.edu.

Funding

Cardioscopically-guided Valve Repair in the Beating HeartR01HL124020 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Pierre E Dupont · 2014 to 2026
$9.7M
NHLBI NIH HHS R01 HL124020
6 · The paper itself

Abstract

purposeThere remains a paucity of direct visualization techniques for beating-heart intracardiac procedures. To address this need, we evaluated a novel cardioscope in the context of aortic paravalvular leaks (PVLs) localization and closure. DESCRIPTION: A porcine aortic PVL model was created using a custom-made bioprosthetic valve, and PVL presence was verified by epicardial echocardiography. Transapical delivery of occlusion devices guided solely by cardioscopy was attempted 13 times in a total of three pigs. Device retrieval after release was attempted six times. Echocardiography, morphologic evaluation, and delivery time were used to assess results. EVALUATION: Cardioscopic imaging enabled localization of PVLs via visualization of regurgitant jet flow in a paravalvular channel at the base of the prosthetic aortic valve. Occluders were successfully placed in 11 of 13 attempts (84.6%), taking on average 3:03 ± 1:34 min. Devices were cardioscopically removed successfully in three of six attempts (50%), taking 3:41 ± 1:46 min. No damage to the ventricle or annulus was observed at necropsy.

conclusionsCardioscopy can facilitate intracardiac interventions by providing direct visualization of anatomic structures inside the blood-filled, beating-heart model.

Indexed as

AnimalsAortic Valve InsufficiencyCardiac CatheterizationCardiac Surgical ProceduresDisease Models, AnimalEchocardiography, Three-DimensionalEchocardiography, TransesophagealEndoscopyHeart Valve ProsthesisMitral Valve InsufficiencyProsthesis FailureReoperationSwine

Identifiers

PMID28838487
PMCPMC5572817

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.