ArticleThe Journal of infectious diseases2017
Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents.
Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Breast cancer survivors' typhoid vaccine responses: Chemotherapy, obesity, and fitness make a difference.Brain, behavior, and immunity · 2022Trial
- Herpes Zoster and Frailty in Older Adults: a Systematic Review.Canadian geriatrics journal : CGJ · 2026Review
- Association between shingles vaccination and slower biological aging: evidence from a US population-based cohort study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- NMR Spectroscopy-Based Lipoprotein and Glycoprotein Biomarkers Differentiate Acute and Chronic Inflammation in Diverse Healthy and Disease Population Cohorts.Journal of proteome research · 2025Article
- NMR spectroscopy derived plasma biomarkers of inflammation in human populations: Influences of age, sex and adiposity.PloS one · 2025Article
- Dietary fatty acids differentially affect secretion of pro-inflammatory cytokines in human THP-1 monocytes.Scientific reports · 2023Article
- Immunosenescence and inflamm-ageing in COVID-19.Ageing research reviews · 2023Review
- Article
- Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells.Immunity & ageing : I & A · 2022Article
- Third dose of the BNT162b2 vaccine in heart transplant recipients: Immunogenicity and clinical experience.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
- SARS-CoV-2, COVID-19 and the Ageing Immune System.Nature aging · 2021Article
- The frequency of interleukin-1β-producing monocytes is significantly associated with varicella-zoster responses of nursing home residents.Clinical and experimental immunology · 2021Article
- Pattern of inflammatory immune response determines the clinical course and outcome of COVID-19: unbiased clustering analysis.Scientific reports · 2021Article
- Dynamic Immune/Inflammation Precision Medicine: The Good and the Bad Inflammation in Infection and Cancer.Frontiers in immunology · 2021Review
- Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity.Immune network · 2019Review
- Chronic inflammation in the etiology of disease across the life span.Nature medicine · 2019Review
- Acute phase protein response to viral infection and vaccination.Archives of biochemistry and biophysics · 2019Review
- Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people.Immunity & ageing : I & A · 2019Article
- Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination.Journal of translational medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Background: Elderly long-term care residents often exhibit a myriad of risk factors for immune dysfunction, including chronic inflammation and multiple comorbid conditions, which undoubtedly contribute to their enhanced susceptibility to infection. Hence, understanding the factors required for optimal vaccine responsiveness is critical. Methods: We examined 187 elderly nursing home residents (aged 80-102 years) and 50 community-dwelling seniors (aged 60-75 years) immunized with the live-attenuated varicella-zoster virus (VZV) vaccine. Specifically, we examined whether vaccine responsiveness was associated with serum C-reactive protein (CRP), tumor necrosis factor, interleukin 1β, 6, and 10, leukocyte telomere length, chronic disease status, and frailty. Results: Elderly participants had significantly higher levels of CRP, tumor necrosis factor, and interleukin 6 and shorter leukocyte telomere length. Vaccine responsiveness was inversely related to the CRP level in elderly participants, but not seniors, and those with congestive heart failure were less likely to achieve a 2-fold response (odds ratio, 0.08). The latter relationship is probably due to immunosenescence, because heart failure was associated with increased senescent CD4+ T cells, and reduced naive and effector and central memory CD8+ T cells. Conclusions: In summary, these data improve our understanding of vaccine responsiveness for those in long-term care, suggesting that certain risk factors are associated with a greater likelihood of vaccine failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.