ArticlePsychiatry research. Neuroimaging2017
Precuneus abnormalities in middle-aged to older adults with depressive symptoms: An analysis of BDI-II symptom dimensions.
Article in Psychiatry research. Neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Superior frontal and hippocampal structures associated with onset versus recurrence of mood disorders in monozygotic twins.Molecular psychiatry · 2026Article
- Investigation of altered spontaneous brain activity in patients with bronchial asthma using the percent amplitude of fluctuation method: a resting-state functional MRI study.Frontiers in human neuroscience · 2023Article
- Depressive Symptoms in Older Adults via Multimodal Markers on Magnetic Resonance Imaging: A Literature Review.JAR life · 2023Article
- Brain structure and connectivity in psoriasis and associations with depression and inflammation; findings from the UK biobank.Brain, behavior, & immunity - health · 2022Article
- Subthreshold depressive symptoms relate to cuneus structure: Thickness asymmetry and sex differences.Journal of psychiatric research · 2022Article
- Depressive Symptom Dimensions and Their Association with Hippocampal and Entorhinal Cortex Volumes in Community Dwelling Older Adults.Frontiers in aging neuroscience · 2018Article
- Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults.Journal of psychiatry & neuroscience : JPNArticle
- Altered resting-state functional connectivity in individuals at risk for Alzheimer's disease: a longitudinal study.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
We recently reported age-related increases in left precuneus cortical thickness (CT) in older adults with elevated total depressive symptoms. However, it is unclear whether abnormalities in precuneus surface area (SA) are also evident and whether specific symptom dimensions of depression moderated age effects on these measurements. Seventy-three adults completed the Beck Depression Inventory - 2nd edition (BDI-II) and underwent structural neuroimaging. Measures of CT and SA were extracted from the right and left precuneus via FreeSurfer. Regression models included regions of interest as dependent variables, with age, BDI-II subscale scores (e.g., affective, cognitive, and somatic symptoms), and their interactions as independent variables, controlling for mean hemispheric thickness (for CT) or total intracranial volume (for SA). A significant age × somatic symptom interaction was found for left precuneus CT, such that elevated levels of somatic symptoms were significantly associated with age-related cortical thinning. No depressive symptom dimensions moderated the relationship between age and SA, suggesting that CT may be a more sensitive measure of brain abnormalities in middle-aged to older adults with depressive symptoms.
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Registered trials
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