Evidence map›Paper›PMID 28837777›Full record

ArticleChemical research in toxicology2017

Arsenite Binds to the Zinc Finger Motif of TIP60 Histone Acetyltransferase and Induces Its Degradation via the 26S Proteasome.

Lok Ming Tam, Ji Jiang, Pengcheng Wang, Lin Li, Weili Miao, Xuejiao Dong, Yinsheng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Integration of epigenetics into ecotoxicology: insights and fundamental research needs.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  2. Article
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  5. Review
  6. Arsenic and cancer: Evidence and mechanisms.Advances in pharmacology (San Diego, Calif.) · 2023
    Article
  7. Epigenomic reprogramming in iAs-mediated carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lok Ming TamEnvironmental Toxicology Graduate Program, ‡Cell, Molecular, and Developmental Biology Graduate Program, and §Department of Chemistry, University of California at Riverside , Mail Drop 027, Riverside, California 92521-0403, United States.
Ji JiangEnvironmental Toxicology Graduate Program, ‡Cell, Molecular, and Developmental Biology Graduate Program, and §Department of Chemistry, University of California at Riverside , Mail Drop 027, Riverside, California 92521-0403, United States.
Pengcheng WangEnvironmental Toxicology Graduate Program, ‡Cell, Molecular, and Developmental Biology Graduate Program, and §Department of Chemistry, University of California at Riverside , Mail Drop 027, Riverside, California 92521-0403, United States.
Lin LiEnvironmental Toxicology Graduate Program, ‡Cell, Molecular, and Developmental Biology Graduate Program, and §Department of Chemistry, University of California at Riverside , Mail Drop 027, Riverside, California 92521-0403, United States.
Weili MiaoEnvironmental Toxicology Graduate Program, ‡Cell, Molecular, and Developmental Biology Graduate Program, and §Department of Chemistry, University of California at Riverside , Mail Drop 027, Riverside, California 92521-0403, United States.
Xuejiao DongEnvironmental Toxicology Graduate Program, ‡Cell, Molecular, and Developmental Biology Graduate Program, and §Department of Chemistry, University of California at Riverside , Mail Drop 027, Riverside, California 92521-0403, United States.
Yinsheng WangEnvironmental Toxicology Graduate Program, ‡Cell, Molecular, and Developmental Biology Graduate Program, and §Department of Chemistry, University of California at Riverside , Mail Drop 027, Riverside, California 92521-0403, United States.ORCID 0000-0001-5565-283X
University of California, Riverside · US

Funding

Enzymatic Conversions of Tet-mediated Oxidation Products of 5-MethylcytosineR21ES025392 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2015 to 2016
$425k
NIEHS NIH HHS R21 ES025392
6 · The paper itself

Abstract

Arsenic is a ubiquitous environmental contaminant with widespread public health concern. Epidemiological studies have revealed that chronic human exposure to arsenic in drinking water is associated with the prevalence of skin, lung, and bladder cancers. Aberrant histone modifications (e.g., methylation, acetylation, and ubiquitination) were previously found to be accompanied by arsenic exposure; thus, perturbation of epigenetic pathways is thought to contribute to arsenic carcinogenesis. Arsenite is known to interact with zinc finger motifs of proteins, and zinc finger motif is present in and indispensable for the enzymatic activities of crucial histone-modifying enzymes especially the MYST family of histone acetyltransferases (e.g., TIP60). Hence, we reasoned that trivalent arsenic may target the zinc finger motif of these enzymes, disturb their enzymatic activities, and alter histone acetylation. Herein, we found that As

Indexed as

AcetylationArsenitesBiotinDithiothreitolHEK293 CellsHistone AcetyltransferasesHistonesHumansLeupeptinsLysine Acetyltransferase 5Proteasome Endopeptidase ComplexProtein BindingSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationUbiquitinZinc FingersarseniteArsenitesATP dependent 26S proteasebenzyloxycarbonylleucyl-leucyl-leucine aldehydeBiotinDithiothreitolHistone AcetyltransferasesHistonesKAT5 protein, humanLeupeptinsLysine Acetyltransferase 5Proteasome Endopeptidase ComplexUbiquitin

Identifiers

PMID28837777
PMCPMC5620024
OpenAlexW2750499562

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.