ArticlePloS one2017
Clinical utility of the UCSD Performance-Based Skills Assessment-Brief (UPSA-B) in adults living with HIV: Associations with neuropsychological impairment and patient-reported everyday functioning difficulties.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05130853 (Social Cognition Individualized Activities Lab), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Social Cognition Individualized Activities Lab (SoCIAL) for the Training of Social Cognition and Narrative Enhancement in Patients With Schizophrenia: A Randomized Controlled Study to Assess Efficacy and Generalization to Real-life Functioning
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of performance-based functional capacity measures for use in Huntington's disease and evaluation of their suitability for clinical trials.Journal of Huntington's disease · 2025Pooled it
- Can individualized-targeted computerized cognitive training improve everyday functioning in adults with HIV-associated neurocognitive disorder?Applied neuropsychology. AdultTrial
- Effectiveness of a social cognition remediation intervention for patients with schizophrenia: a randomized-controlled study.Annals of general psychiatry · 2024Article
- Self-perceived cognitive fluctuations and their relationship to everyday functioning in older adults with and without HIV disease.The Clinical neuropsychologist · 2024Article
- An evaluation of the moderating effects of routine and busyness on the relationship between prospective memory and everyday functioning in older persons with HIV disease.Journal of clinical and experimental neuropsychology · 2024Article
- Combined effects of older age and HIV disease on changes in everyday functioning over one year.Journal of neurovirology · 2022Article
- REM Sleep Behavior Disorder in Parkinson's Disease: Change in Cognitive, Psychiatric, and Functional Outcomes from Baseline to 16-47-Month Follow-Up.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022Article
- Social Cognition Individualized Activities Lab for Social Cognition Training and Narrative Enhancement in Patients With Schizophrenia: A Randomized Controlled Study to Assess Efficacy and Generalization to Real-Life Functioning (Prot. n°: NCT05130853).Frontiers in psychiatry · 2022Article
- Rates of Cognitive and Functional Impairments in Older Adults Residing in a Continuing Care Senior Housing Community.Journal of the International Neuropsychological Society : JINS · 2022Article
- Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection.Brain sciences · 2021Article
- The University of California San Diego performance-based skills assessment: a useful tool to detect mild everyday functioning difficulties in HIV-infected patients with very good immunological condition.Journal of neurovirology · 2020Article
- Association of HIV serostatus and metabolic syndrome with neurobehavioral disturbances.Journal of neurovirology · 2020Article
- Depression and aging with HIV: Associations with health-related quality of life and positive psychological factors.Journal of affective disorders · 2019Article
- Metabolic Syndrome and Neurocognitive Deficits in HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Frequency and Correlates of Subjective Cognitive Impairment in HIV Disease.AIDS and behavior · 2019Article
- Inflammation Relates to Poorer Complex Motor Performance Among Adults Living With HIV on Suppressive Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- A composite of multisystem injury and neurocognitive impairment in HIV infection: association with everyday functioning.Journal of neurovirology · 2018Observational
- Overview of measurement-based positive psychiatry.Nordic journal of psychiatry · 2018Review
- Frailty in Comorbid HIV and Lifetime Methamphetamine Use Disorder: Associations with Neurocognitive and Everyday Functioning.AIDS research and human retrovirusesArticle
- Frailty and Neurocognitive Impairment: Impacts on Quality of Life in HIV.The Journal of the Association of Nurses in AIDS Care : JANACObservational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveRequiring only 10-15 minutes to complete, the UCSD Performance-Based Skills Assessment (UPSA-B) has high clinical utility as a brief measure of functional capacity. This study aimed to validate the UPSA-B in adults living with HIV/AIDS (HIV+), and identify whether the UPSA-B can be used as an indicator of functional dependence in this population.
methodOne hundred and three HIV+ adults and 91 HIV- adults completed a comprehensive neuropsychological and neuromedical battery, including a self-report measure of functional status (IADL Dependence vs. IADL Independence), an objective measure of functional capacity (UPSA-B), and a self-report measure of mood states including a subscale related to cognitive difficulties (Profile of Mood States [POMS]-Confusion/Bewilderment subscale).
resultsHIV+ participants had significantly lower UPSA-B scores than their HIV- counterparts (p = 0.02), although this fell to a trend (p = 0.08) when including covariates. Among the HIV+ group, higher UPSA-B scores were related to better neuropsychological ability, but unrelated to self-reported functional independence. Conversely, UPSA-B scores were unrelated to participant-reported cognitive difficulties on the POMS Confusion/Bewilderment subscale. An ROC curve was generated to determine the optimal UPSA-B value for discriminating between normal neuropsychological functioning versus neuropsychological impairment, with results indicating an optimal cutoff of 79. The UPSA-B identified HIV+ persons with cognitive impairment with 70.9% accuracy.
conclusionsThe UPSA-B was able to differentiate neuropsychological impairment from no impairment among HIV+ participants and holds promise as a clinical screening tool in this population. However, indicators of functional disability among adults living with HIV is still not well understood and is likely multifactorial in nature. These data highlight the complex interplay between objective functional capacity, neurocognitive ability, subjective cognitive symptoms, and functional dependence.
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